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Title: Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis
Authors: Branco, Diogo Martins 
Arduíno, Daniela M. 
Esteves, A. Raquel 
Silva, Diana F. F. 
Cardoso, Sandra M. 
Oliveira, C. R. 
Keywords: Parkinson’s disease; dopamine; alpha-synuclein; mitochondria; proteasome
Issue Date: 2010
Publisher: Frontiers Media S.A.
Project: FCT - BII grant 
GAPI of Faculdade de Medicina da Universidade de Coimbra, Portugal 
PTDC/SAU-NEU/102710/2008, FCT 
Serial title, monograph or event: Frontiers in Aging Neuroscience
Volume: 2
Issue: MAY
Abstract: Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading hypothesis for the death of specific groups of neurons establishes that mitochondrial dysfunction, alterations in the ubiquitin-proteasomal system (UPS), and oxidative stress are major events that act synergistically causing this devastating disease. In this review we will focus on mitochondrial impairment and its implications on proteasomal function and alpha-synuclein aggregation. We will address the role of mitochondria and proteasome cross-talk in the neuronal loss that leads to PD and discuss how this knowledge might further improve patient therapy.
ISSN: 16634365
DOI: 10.3389/fnagi.2010.00017
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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