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Title: Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: when mitochondria get nasty
Authors: Arduíno, Daniela M. 
Esteves, A. Raquel 
Cardoso, Sandra M. 
Issue Date: 20-Feb-2011
Publisher: Hindawi
Project: PTDC/ SAU-NEU/102710/2008 
SFRHD/BD/38743/ 2007 
Serial title, monograph or event: Parkinson's Disease
Volume: 2011
Abstract: Understanding the molecular basis of Parkinson's disease (PD) has proven to be a major challenge in the field of neurodegenerative diseases. Although several hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of PD, a growing body of evidence has highlighted the role of mitochondrial dysfunction and the disruption of the mechanisms of mitochondrial dynamics in PD and other parkinsonian disorders. In this paper, we comment on the recent advances in how changes in the mitochondrial function and mitochondrial dynamics (fusion/fission, transport, and clearance) contribute to neurodegeneration, specifically focusing on PD. We also evaluate the current controversies in those issues and discuss the role of fusion/fission dynamics in the mitochondrial lifecycle and maintenance. We propose that cellular demise and neurodegeneration in PD are due to the interplay between mitochondrial dysfunction, mitochondrial trafficking disruption, and impaired autophagic clearance.
ISSN: 2042-0080
DOI: 10.4061/2011/767230
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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