Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110006
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mega, Cristina | - |
dc.contributor.author | Teixeira-Lemos, Edite | - |
dc.contributor.author | Vala, Helena | - |
dc.contributor.author | Fernandes, Rosa | - |
dc.contributor.author | Oliveira, Jorge | - |
dc.contributor.author | Mascarenhas-Melo, Filipa | - |
dc.contributor.author | Teixeira, F. | - |
dc.contributor.author | Reis, F. | - |
dc.date.accessioned | 2023-11-13T08:59:28Z | - |
dc.date.available | 2023-11-13T08:59:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1687-5214 | pt |
dc.identifier.issn | 1687-5303 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110006 | - |
dc.description.abstract | This study was performed to assess the effect of chronic low-dose sitagliptin, a dipeptidyl peptidase 4 inhibitor, on metabolic profile and on renal lesions aggravation in a rat model of type-2 diabetic nephropathy, the Zucker diabetic fatty (ZDF) rat. Diabetic and obese ZDF (fa/fa) rats and their controls ZDF (+/+) were treated for 6 weeks with vehicle (control) or sitagliptin (10 mg/kg/bw). Blood/serum glucose, HbA1c, insulin, Total-c, TGs, urea, and creatinine were assessed, as well as kidney glomerular and tubulointerstitial lesions (interstitial fibrosis/tubular atrophy), using a semiquantitative rating from 0 (absent/normal) to 3 (severe and extensive damage). Vascular lesions were scored from 0-2. Sitagliptin in the diabetic rats promoted an amelioration of glycemia, HbA1c, Total-c, and TGs, accompanied by a partial prevention of insulinopenia. Furthermore, together with urea increment prevention, renal lesions were ameliorated in the diabetic rats, including glomerular, tubulointerstitial, and vascular lesions, accompanied by reduced lipid peroxidation. In conclusion, chronic low-dose sitagliptin treatment was able to ameliorate diabetic nephropathy, which might represent a key step forward in the management of T2DM and this serious complication. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Blood Glucose | pt |
dc.subject.mesh | Body Weight | pt |
dc.subject.mesh | Diabetes Mellitus, Type 2 | pt |
dc.subject.mesh | Diabetic Nephropathies | pt |
dc.subject.mesh | Dipeptidyl-Peptidase IV Inhibitors | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Dose-Response Relationship, Drug | pt |
dc.subject.mesh | Insulin | pt |
dc.subject.mesh | Kidney Glomerulus | pt |
dc.subject.mesh | Lipid Peroxidation | pt |
dc.subject.mesh | Lipids | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Obesity | pt |
dc.subject.mesh | Pyrazines | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Rats, Zucker | pt |
dc.subject.mesh | Sitagliptin Phosphate | pt |
dc.subject.mesh | Treatment Outcome | pt |
dc.subject.mesh | Triazoles | pt |
dc.title | Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat) | pt |
dc.type | article | - |
degois.publication.firstPage | 162092 | pt |
degois.publication.lastPage | 12 | pt |
degois.publication.title | Experimental Diabetes Research | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2011/162092 | pt |
degois.publication.volume | 2011 | pt |
dc.date.embargo | 2011-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | 0000-0001-7828-2296 | - |
crisitem.author.orcid | 0000-0003-0786-6280 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais |
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Diabetic-nephropathy-amelioration-by-a-lowdose-sitagliptin-in-an-animal-model-of-type-2-diabetes-Zucker-diabetic-fatty-ratExperimental-Diabetes-Research.pdf | 2.55 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License