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https://hdl.handle.net/10316/109866
Title: | Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats | Authors: | Rodrigues, Márcio Alves, Gilberto Lourenço, Nulita Falcão, Amílcar |
Issue Date: | 2012 | Publisher: | Hindawi | Project: | SFRH/BD/61901/2009 SFRH/BPD/46826/2008 |
Serial title, monograph or event: | Evidence-based Complementary and Alternative Medicine | Volume: | 2012 | Abstract: | Paullinia cupana is used in weight-loss programs as a constituent of medicinal/dietary supplements. This study aimed to assess a potential herb-drug interaction among a standardized (certified) Paullinia cupana extract and amiodarone (narrow therapeutic index drug) in rats. In a first pharmacokinetic study rats were simultaneously coadministered with a single dose of Paullinia cupana (821 mg/kg, p.o.) and amiodarone (50 mg/kg, p.o.), and in a second study rats were pretreated during 14 days with Paullinia cupana (821 mg/kg/day, p.o.) receiving amiodarone (50 mg/kg, p.o.) on the 15th day. Rats of the control groups received the corresponding volume of vehicle. Blood samples were collected at several time points after amiodarone dosing, and several tissues were harvested at the end of the experiments (24 h after dose). Plasma and tissue concentrations of amiodarone and its major metabolite (mono-N-desethylamiodarone) were measured and analysed. A significant reduction in the peak plasma concentration (73.2%) and in the extent of systemic exposure (57.8%) to amiodarone was found in rats simultaneously treated with Paullinia cupana and amiodarone; a decrease in tissue concentrations was also observed. This paper reports for the first time an herb-drug interaction between Paullinia cupana extract and amiodarone, which determined a great decrease on amiodarone bioavailability in rats. | URI: | http://hdl.handle.net/10316/109866 | ISSN: | 1741-427X 1741-4288 |
DOI: | 10.1155/2012/428560 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
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Herbdrug-interaction-of-Paullinia-cupana-Guarana-seed-extract-on-the-pharmacokinetics-of-amiodarone-in-ratsEvidencebased-Complementary-and-Alternative-Medicine.pdf | 1.46 MB | Adobe PDF | View/Open |
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