Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/109725
DC FieldValueLanguage
dc.contributor.authorGuedes, J.-
dc.contributor.authorCardoso, A. L. C.-
dc.contributor.authorLima, M. C. Pedroso de-
dc.date.accessioned2023-10-24T10:57:03Z-
dc.date.available2023-10-24T10:57:03Z-
dc.date.issued2013-
dc.identifier.issn1740-2522pt
dc.identifier.issn1740-2530pt
dc.identifier.urihttps://hdl.handle.net/10316/109725-
dc.description.abstractMicroRNAs (miRNAs) are an abundant class of small noncoding RNA molecules that play an important role in the regulation of gene expression at the posttranscriptional level. Due to their ability to simultaneously modulate the fate of different genes, these molecules are particularly well suited to act as key regulators during immune cell differentiation and activation, and their dysfunction can contribute to pathological conditions associated with neuroinflammation. Recent studies have addressed the role of miRNAs in the differentiation of progenitor cells into microglia and in the activation process, aiming at clarifying the origin of adult microglia cells and the contribution of the central nervous system (CNS) environment to microglia phenotype, in health and disease. Altered expression of several miRNAs has been associated with Alzheimer's disease, multiple sclerosis, and ischemic injury, hence strongly advocating the use of these small molecules as disease markers and new therapeutic targets. This review summarizes the recent advances in the field of miRNA-mediated regulation of microglia development and activation. We discuss the role of specific miRNAs in the maintenance and switching of microglia activation states and illustrate the potential of this class of nucleic acids both as biomarkers of inflammation and new therapeutic tools for the modulation of microglia behavior in the CNS.pt
dc.language.isoengpt
dc.publisherHindawipt
dc.relationPTDC/BIM-MEC/0651/2012pt
dc.relationPest- C/SAU/LA0001/2011pt
dc.relationSFRH/BD/51677/2011pt
dc.relationSFRH/BPD/46228/2008pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subject.meshBiomarkerspt
dc.subject.meshCell Differentiationpt
dc.subject.meshCentral Nervous Systempt
dc.subject.meshCytokinespt
dc.subject.meshGene Expression Regulationpt
dc.subject.meshHumanspt
dc.subject.meshImmunity, Innatept
dc.subject.meshInflammationpt
dc.subject.meshMacrophage Activationpt
dc.subject.meshMacrophagespt
dc.subject.meshMicroRNAspt
dc.subject.meshMicrogliapt
dc.subject.meshNeural Stem Cellspt
dc.subject.meshNeurodegenerative Diseasespt
dc.subject.meshOligonucleotides, Antisensept
dc.titleInvolvement of microRNA in microglia-mediated immune responsept
dc.typearticle-
degois.publication.firstPage186872pt
degois.publication.lastPage11pt
degois.publication.titleClinical and Developmental Immunologypt
dc.peerreviewedyespt
dc.identifier.doi10.1155/2013/186872pt
degois.publication.volume2013pt
dc.date.embargo2013-01-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-1844-5027-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons