Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109366
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Reboiro-Jato, Miguel | - |
dc.contributor.author | Arrais, Joel P. | - |
dc.contributor.author | Oliveira, José Luís | - |
dc.contributor.author | Fdez-Riverola, Florentino | - |
dc.date.accessioned | 2023-10-11T09:54:12Z | - |
dc.date.available | 2023-10-11T09:54:12Z | - |
dc.date.issued | 2014-01-30 | - |
dc.identifier.issn | 1471-2105 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109366 | - |
dc.description.abstract | Background: The diagnosis and prognosis of several diseases can be shortened through the use of different large-scale genome experiments. In this context, microarrays can generate expression data for a huge set of genes. However, to obtain solid statistical evidence from the resulting data, it is necessary to train and to validate many classification techniques in order to find the best discriminative method. This is a time-consuming process that normally depends on intricate statistical tools. Results: geneCommittee is a web-based interactive tool for routinely evaluating the discriminative classification power of custom hypothesis in the form of biologically relevant gene sets. While the user can work with different gene set collections and several microarray data files to configure specific classification experiments, the tool is able to run several tests in parallel. Provided with a straightforward and intuitive interface, geneCommittee is able to render valuable information for diagnostic analyses and clinical management decisions based on systematically evaluating custom hypothesis over different data sets using complementary classifiers, a key aspect in clinical research. Conclusions: geneCommittee allows the enrichment of microarrays raw data with gene functional annotations, producing integrated datasets that simplify the construction of better discriminative hypothesis, and allows the creation of a set of complementary classifiers. The trained committees can then be used for clinical research and diagnosis. Full documentation including common use cases and guided analysis workflows is freely available at http://sing.ei.uvigo.es/GC/. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | Spanish Ministry of Science and Innovation, Plan E of the Spanish Government and the European Union through the ERDF (TIN2009-14057-C03-02), Agrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa (2012/273 | pt |
dc.relation | European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 200754 - the GEN2PHEN project. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Computational Biology | pt |
dc.subject.mesh | Disease | pt |
dc.subject.mesh | Gene Expression Profiling | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | User-Computer Interface | pt |
dc.subject.mesh | Databases, Genetic | pt |
dc.subject.mesh | Internet | pt |
dc.subject.mesh | Software | pt |
dc.title | geneCommittee: a web-based tool for extensively testing the discriminatory power of biologically relevant gene sets in microarray data classification | pt |
dc.type | article | - |
degois.publication.firstPage | 31 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | BMC Bioinformatics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/1471-2105-15-31 | pt |
degois.publication.volume | 15 | pt |
dc.date.embargo | 2014-01-30 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CISUC - Centre for Informatics and Systems of the University of Coimbra | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-4937-2334 | - |
Appears in Collections: | I&D CISUC - Artigos em Revistas Internacionais FCTUC Eng.Informática - Artigos em Revistas Internacionais |
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