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Title: | Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? | Authors: | Görlach, Agnes Dimova, Elitsa Y. Petry, Andreas Martínez-Ruiz, Antonio Hernansanz-Agustín, Pablo Rolo, Anabela P. Palmeira, Carlos M. Kietzmann, Thomas |
Keywords: | Freeradicals; Diets; Oxygen; Metabolism; Diseases; Mitochondria; Hypoxia; Diabetes; Obesity | Issue Date: | Dec-2015 | Publisher: | Elsevier | Project: | ThisworkwassupportedbygrantsfromGer- man ResearchFoundation(DFG-GO709/4-5),DZHK(German Centre forCardiovascularResearch),GermanFederalMinistryof Education andResearch(Acidox,Epiros),toAG.WorkintheAMR lab wassupportedbygrantsfromtheSpanishGovernment(PI12/ 00875)andfromtheFundaciónDomingoMartínez;AMRandPHA aresupportedbytheI3SNSandFPUprogramsoftheSpanish Government,respectively.WorkintheTKlabwassupportedby grants fromtheFinnishAcademyofSciences,theSigridJuselius Foundation, CIMO,andBiocenterOulu.Someoftheauthorswere supported bytheEuropeanCooperationinScienceandTechnology (COSTActionBM1203/EU‐ROS). | Serial title, monograph or event: | Redox Biology | Volume: | 6 | Abstract: | Within the last twenty years the view on reactive oxygen species (ROS) has changed; they are no longer only considered to be harmful but also necessary for cellular communication and homeostasis in different organisms ranging from bacteria to mammals. In the latter, ROS were shown to modulate diverse physiological processes including the regulation of growth factor signaling, the hypoxic response, inflammation and the immune response. During the last 60-100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake, decreased energy expenditure as well as the appearance of alcoholism and smoking; These changes were shown to contribute to generation of ROS which are, at least in part, associated with the occurrence of several chronic diseases like adiposity, atherosclerosis, type II diabetes, and cancer. In this review we discuss aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues. | URI: | https://hdl.handle.net/10316/109301 | ISSN: | 22132317 | DOI: | 10.1016/j.redox.2015.08.016 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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