Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109300
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferreira, Brigida Costa | - |
dc.contributor.author | Marques, Rui Vale | - |
dc.contributor.author | Khouri, Leila | - |
dc.contributor.author | Santos, Tânia | - |
dc.contributor.author | Sá-Couto, Pedro | - |
dc.contributor.author | do Carmo Lopes, Maria | - |
dc.date.accessioned | 2023-10-09T11:05:37Z | - |
dc.date.available | 2023-10-09T11:05:37Z | - |
dc.date.issued | 2015-02-15 | - |
dc.identifier.issn | 1748-717X | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109300 | - |
dc.description.abstract | Purpose: To evaluate the differences between three methods of classification of recurrences in patients with head and neck tumours treated with Radiation Therapy (RT). Materials and methods: 367 patients with head and neck tumours were included in the study. Tumour recurrences were delineated in the CT images taken during patient follow-up and deformable registration was used to transfer this volume into the planning CT. The methods used to classify recurrences were: method CTV quantified the intersection volume between the recurrence and the Clinical Target Volume (CTV); method TV quantified the intersection between the Treated Volume and the recurrence (for method CTV and TV, recurrences were classified in-field if more than 95% of their volume were inside the volume of interest, marginal if the intersection was between 20-95% and outfield otherwise); and method COM was based on the position of the Centre Of Mass of the recurrence. A dose assessment in the recurrence volume was also made. Results: The 2-year Kaplan-Meier locoregional recurrence incidence was 10%. Tumour recurrences occurred in 22 patients in a mean time of 16.5 ± 9.4 months resulting in 28 recurrence volumes. The percentage of in-field recurrences for methods CTV, TV and COM was 7%, 43% and 50%, respectively. Agreement between the three methods in characterizing individually in-field and marginal recurrences was found only in six cases. Methods CTV and COM agreed in 14. The percentage of outfield recurrences was 29% using all methods. For local recurrences (in-field or marginal to gross disease) the average difference between the prescribed dose and D98% in the recurrence volume was -5.2 ± 3.5% (range: -10.1%-0.9%). Conclusions: The classification of in-field and marginal recurrences is very dependent on the method used to characterize recurrences. Using methods TV and COM the largest percentage of tumour recurrences occurred in-field in tissues irradiated with high doses. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | FCT - PEst-C/CTM/LA0025/2011 | pt |
dc.relation | CIDMA - Center for Research and Development in Mathematics and Applications | pt |
dc.relation | FCT -PEst-OE/MAT/UI4106/2014 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Head and neck tumours | pt |
dc.subject | Radiation therapy | pt |
dc.subject | Characterization of tumour recurrences | pt |
dc.subject | Geometric methods | pt |
dc.subject | Dosimetric assessment | pt |
dc.subject.mesh | Adolescent | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Aged, 80 and over | pt |
dc.subject.mesh | Carcinoma, Squamous Cell | pt |
dc.subject.mesh | Child | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Follow-Up Studies | pt |
dc.subject.mesh | Head and Neck Neoplasms | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Neoplasm Recurrence, Local | pt |
dc.subject.mesh | Neoplasm Staging | pt |
dc.subject.mesh | Prognosis | pt |
dc.subject.mesh | Radiotherapy | pt |
dc.subject.mesh | Radiotherapy Planning, Computer-Assisted | pt |
dc.subject.mesh | Radiotherapy, Intensity-Modulated | pt |
dc.subject.mesh | Retrospective Studies | pt |
dc.subject.mesh | Risk Assessment | pt |
dc.subject.mesh | Survival Rate | pt |
dc.subject.mesh | Tomography, X-Ray Computed | pt |
dc.subject.mesh | Young Adult | pt |
dc.title | Assessment and topographic characterization of locoregional recurrences in head and neck tumours | pt |
dc.type | article | - |
degois.publication.firstPage | 41 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Radiation Oncology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/s13014-015-0345-4 | pt |
degois.publication.volume | 10 | pt |
dc.date.embargo | 2015-02-15 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.orcid | 0000-0002-5325-3090 | - |
Appears in Collections: | FCTUC Física - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Assessment-and-topographic-characterization-of-locoregional-recurrences-in-head-and-neck-tumoursRadiation-Oncology.pdf | 579.9 kB | Adobe PDF | View/Open |
Page view(s)
31
checked on May 8, 2024
Download(s)
14
checked on May 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License