Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/109229
DC FieldValueLanguage
dc.contributor.authorMadeira, Maria H.-
dc.contributor.authorBoia, Raquel-
dc.contributor.authorSantos, Paulo-
dc.contributor.authorAmbrósio, A. Francisco-
dc.contributor.authorSantiago, Ana R.-
dc.date.accessioned2023-10-04T09:36:06Z-
dc.date.available2023-10-04T09:36:06Z-
dc.date.issued2015-
dc.identifier.issn0962-9351pt
dc.identifier.issn1466-1861pt
dc.identifier.urihttps://hdl.handle.net/10316/109229-
dc.description.abstractRetinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.pt
dc.language.isoengpt
dc.publisherHindawipt
dc.relationSFRH/BD/75839/2011pt
dc.relationPTDC/BIM-MEC/0913/2012pt
dc.relationPTDC/NEU-OSD/1113/2012pt
dc.relationPEst-C/SAU/UI3282/2011–2013pt
dc.relationPEst-C/SAU/LA0001/ 2013-2014pt
dc.relationAIBILI, Portugalpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subject.meshDiabetic Retinopathypt
dc.subject.meshGlaucomapt
dc.subject.meshHumanspt
dc.subject.meshInflammationpt
dc.subject.meshMacular Degenerationpt
dc.subject.meshMicrogliapt
dc.subject.meshNeurodegenerative Diseasespt
dc.subject.meshRetinapt
dc.subject.meshRetinal Degenerationpt
dc.titleContribution of microglia-mediated neuroinflammation to retinal degenerative diseasespt
dc.typearticle-
degois.publication.firstPage673090pt
degois.publication.lastPage15pt
degois.publication.titleMediators of Inflammationpt
dc.peerreviewedyespt
dc.identifier.doi10.1155/2015/673090pt
degois.publication.volume2015pt
dc.date.embargo2015-01-01*
uc.date.periodoEmbargo0pt
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.researchunitISISE - Institute for Sustainability and Innovation in Structural Engineering-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.orcid0000-0001-6282-3553-
crisitem.author.orcid0000-0002-0134-6762-
crisitem.author.orcid0000-0002-0477-1641-
crisitem.author.orcid0000-0002-7541-7041-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
Show simple item record

Page view(s)

79
checked on May 22, 2024

Download(s)

31
checked on May 22, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons