Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/109222
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Ribeiro, Andreza Maria | - |
dc.contributor.author | Figueiras, Ana | - |
dc.contributor.author | Veiga, Francisco | - |
dc.date.accessioned | 2023-10-04T08:34:51Z | - |
dc.date.available | 2023-10-04T08:34:51Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1482-1826 | pt |
dc.identifier.issn | 1482-1826 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109222 | - |
dc.description.abstract | Purpose. Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems. | pt |
dc.language.iso | eng | pt |
dc.publisher | Canadian Society for Pharmaceutical Sciences | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | pt |
dc.title | Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses | pt |
dc.type | article | - |
degois.publication.firstPage | 683 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Journal of Pharmacy and Pharmaceutical Sciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.18433/J3H60P | pt |
degois.publication.volume | 18 | pt |
dc.date.embargo | 2015-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8170-1113 | - |
crisitem.author.orcid | 0000-0002-1041-0068 | - |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Improvements-in-topical-ocular-drug-delivery-systems-Hydrogels-and-contact-lenseJournal-of-Pharmacy-and-Pharmaceutical-Sciences.pdf | 466.52 kB | Adobe PDF | Ver/Abrir |
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