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Title: Effects on gastric mucosa induced by dental bleaching--an experimental study with 6% hydrogen peroxide in rats
Authors: Paula, Anabela Baptista 
Dias, Maria Isabel 
Ferreira, Manuel Marques 
Carrilho, Teresa 
Marto, Carlos Miguel 
Casalta, João
Cabrita, António 
Carrilho, Eunice 
Keywords: Ambulatory monitoring; Bleaching agents; Gastritis; Hydrogen peroxide; Tooth bleaching; Toxicity
Issue Date: Oct-2015
Publisher: Faculdade de Odontologia de Bauru
Serial title, monograph or event: Journal of Applied Oral Science
Volume: 23
Issue: 5
Abstract: The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed. Objective: This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals. Material and Methods: Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically signi􀂿cant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa. Results: The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group. Conclusion: Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.
ISSN: 1678-7757
DOI: 10.1590/1678-775720150235
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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