Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/109156
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Rodrigues, Ricardo J. | - |
dc.contributor.author | Tomé, Ângelo R. | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.date.accessioned | 2023-09-29T09:03:31Z | - |
dc.date.available | 2023-09-29T09:03:31Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1662-4548 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109156 | - |
dc.description.abstract | ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2 receptors (P2R) as well as adenosine receptors upon extracellular ATP catabolism by ecto-nucleotidases. Notably, brain noxious stimuli trigger a sustained increase of extracellular ATP, which plays a key role as danger signal in the brain. This involves a combined action of extracellular ATP in different cell types, namely increasing the susceptibility of neurons to damage, promoting astrogliosis and recruiting and formatting microglia to mount neuroinflammatory responses. Such actions involve the activation of different receptors, as heralded by neuroprotective effects resulting from blockade mainly of P2X7R, P2Y1R and adenosine A2A receptors (A2AR), which hierarchy, cooperation and/or redundancy is still not resolved. These pleiotropic functions of ATP as a danger signal in brain damage prompt a therapeutic interest to multi-target different purinergic receptors to provide maximal opportunities for neuroprotection. | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers Media S.A. | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | ATP | pt |
dc.subject | adenosine | pt |
dc.subject | P2 receptors | pt |
dc.subject | P1 receptors | pt |
dc.subject | ecto-nucleotidases | pt |
dc.subject | P2X7 receptor | pt |
dc.subject | P2Y1 receptor | pt |
dc.subject | A2A receptor | pt |
dc.title | ATP as a multi-target danger signal in the brain | pt |
dc.type | article | - |
degois.publication.firstPage | 148 | pt |
degois.publication.issue | APR | pt |
degois.publication.title | Frontiers in Neuroscience | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fnins.2015.00148 | pt |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2015-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-7631-743X | - |
crisitem.author.orcid | 0000-0001-8671-989X | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ATP as a multi-target danger signal in the brain.pdf | 2.23 MB | Adobe PDF | Ver/Abrir |
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