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Title: The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases
Authors: Reijs, Babette L R
Teunissen, Charlotte E
Goncharenko, Nikolai
Betsou, Fay
Blennow, Kaj
Baldeiras, Inês 
Brosseron, Frederic
Cavedo, Enrica
Fladby, Tormod
Froelich, Lutz
Gabryelewicz, Tomasz
Gurvit, Hakan
Kapaki, Elisabeth
Koson, Peter
Kulic, Luka
Lehmann, Sylvain
Lewczuk, Piotr
Lleó, Alberto 
Maetzler, Walter
de Mendonça, Alexandre
Miller, Anne-Marie
Molinuevo, José L. 
Mollenhauer, Brit
Parnetti, Lucilla
Rot, Uros
Schneider, Anja
Simonsen, Anja Hviid
Tagliavini, Fabrizio 
Tsolaki, Magda
Verbeek, Marcel M.
Verhey, Frans R. J.
Zboch, Marzena
Winblad, Bengt
Scheltens, Philip
Zetterberg, Henrik
Visser, Pieter Jelle
Keywords: Alzheimer’s disease; Parkinson’s disease; biobank; body fluids; cerebrospinal fluid; dementia; neurodegenerative disorders
Issue Date: 2015
Serial title, monograph or event: Frontiers in Neurology
Volume: 6
Issue: OCT
Abstract: Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank.
ISSN: 1664-2295
DOI: 10.3389/fneur.2015.00216
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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