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Title: Gene Association with Leprosy: A Review of Published Data
Authors: Mazini, Priscila Saamara
Alves, Hugo Vicentin
Reis, Pâmela Guimarães
Lopes, Ana Paula 
Sell, Ana Maria
Santos-Rosa, Manuel 
Visentainer, Jeane Eliete Laguila
Rodrigues-Santos, Paulo 
Keywords: leprosy; innate immunity; immune response genes; Mycobacterium leprae
Issue Date: 2015
Publisher: Frontiers Media S.A.
Project: PEst-C/SAU/LA0001/2013-2014 
University of Coimbra 
Serial title, monograph or event: Frontiers in Immunology
Volume: 6
Issue: JAN
Abstract: Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease.
ISSN: 1664-3224
DOI: 10.3389/fimmu.2015.00658
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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