Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/108523
Title: Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles
Authors: Conceição, Mariana 
Mendonça, Liliana 
Nóbrega, Clévio
Gomes, Célia 
Costa, Pedro 
Hirai, Hirokazu
Moreira, João Nuno 
Lima, Maria C. Pedroso de 
Manjunath, N.
Almeida, Luís Pereira de 
Issue Date: Mar-2016
Publisher: Elsevier
Project: PTDC/SAU-FAR/116535/2010 
E-Rare4/0003/2012 
PEst-C/SAU/LA0001/2013-2014 
CENTRO-07-ST24-FEDER-002002,002006,002008 
andbythestrategicprojectUID/ NEU/04539/2013 
Serial title, monograph or event: Data in Brief
Volume: 6
Abstract: In a clinical setting, where multiple administrations of the therapeutic agent are usually required to improve the therapeutic outcome, it is crucial to assess the immunogenicity of the administered nanoparticles. In this data work, we investigated the safety profile of the repeated intravenous administration of brain-targeted stable nucleic acid lipid particles (RVG-9r-targeted SNALPs). To evaluate local activation of the immune system, we performed analysis of mouse tissue homogenates and sections from cerebellum. To investigate peripheral activation of the immune system, we used serum of mice that were intravenously injected with RVG-9r-targeted SNALPs. These data are related and were discussed in the accompanying research article entitled "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype" (Conceição et al., in press) [1].
URI: https://hdl.handle.net/10316/108523
ISSN: 2352-3409
DOI: 10.1016/j.dib.2016.01.017
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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