Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/108486
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Guedes, Joana R. | - |
dc.contributor.author | Santana, Isabel | - |
dc.contributor.author | Cunha, Catarina | - |
dc.contributor.author | Duro, Diana | - |
dc.contributor.author | Almeida, Maria R. | - |
dc.contributor.author | Cardoso, Ana M. | - |
dc.contributor.author | Lima, Maria C. Pedroso de | - |
dc.contributor.author | Cardoso, Ana L. | - |
dc.date.accessioned | 2023-08-30T08:51:27Z | - |
dc.date.available | 2023-08-30T08:51:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2352-8729 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/108486 | - |
dc.description.abstract | Introduction: Mononuclear phagocytes play a critical role during Alzheimer’s disease (AD) pathogenesis due to their contribution to innate immune responses and amyloid beta (Ab) clearance mechanisms. Methods: Blood-derived monocytes (BDMs) and monocyte-derived macrophages (MDMs) were isolated from blood of AD, mild cognitive impairment (MCI) patients, and age-matched healthy controls for molecular and phenotypic comparisons. Results: The chemokine/chemokine receptor CCL2/CCR2 axis was impaired in BDMs fromAD and MCI patients, causing a deficit in cell migration. Changes were also observed in MDM-mediated phagocytosis of Ab fibrils, correlating with alterations in the expression and processing of the triggering receptor expressed on myeloid cells 2 (TREM2). Finally, immune-related microRNAs (miRNAs), including miR-155, -154, -200b, -27b, and -128, were found to be differentially expressed in these cells. Discussion: This work provides evidence that chemotaxis and phagocytosis, two crucial innate immune functions, are impaired in AD and MCI patients. Correlations with miRNA levels suggest an epigenetic contribution to systemic immune dysfunction in AD. | pt |
dc.language.iso | eng | pt |
dc.publisher | Elsevier | pt |
dc.relation | SFRH/BD/ 51677/2011 | pt |
dc.relation | SFRH/BPD/99613/2014 | pt |
dc.relation | PTDC/ BIM-MEC/0651/2012 | pt |
dc.relation | FEDER/COMPETE (PEst-C/ SAU/LA0001/2013-2014) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Alzheimer’s disease | pt |
dc.subject | Monocytes | pt |
dc.subject | Macrophages | pt |
dc.subject | Chemotaxis | pt |
dc.subject | Phagocytosis | pt |
dc.subject | CCR2 | pt |
dc.subject | TREM2 | pt |
dc.subject | miRNAs | pt |
dc.title | MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease | pt |
dc.type | article | - |
degois.publication.firstPage | 7 | pt |
degois.publication.lastPage | 17 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.dadm.2015.11.004 | pt |
degois.publication.volume | 3 | pt |
dc.date.embargo | 2016-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | Center for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC) | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Psychology and Educational Sciences | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-8114-9434 | - |
crisitem.author.orcid | 0000-0002-9818-9862 | - |
crisitem.author.orcid | 0000-0002-1889-5469 | - |
crisitem.author.orcid | 0000-0003-1844-5027 | - |
crisitem.author.orcid | 0000-0003-0551-7255 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease.pdf | 1.14 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License