Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/108486
DC FieldValueLanguage
dc.contributor.authorGuedes, Joana R.-
dc.contributor.authorSantana, Isabel-
dc.contributor.authorCunha, Catarina-
dc.contributor.authorDuro, Diana-
dc.contributor.authorAlmeida, Maria R.-
dc.contributor.authorCardoso, Ana M.-
dc.contributor.authorLima, Maria C. Pedroso de-
dc.contributor.authorCardoso, Ana L.-
dc.date.accessioned2023-08-30T08:51:27Z-
dc.date.available2023-08-30T08:51:27Z-
dc.date.issued2016-
dc.identifier.issn2352-8729pt
dc.identifier.urihttps://hdl.handle.net/10316/108486-
dc.description.abstractIntroduction: Mononuclear phagocytes play a critical role during Alzheimer’s disease (AD) pathogenesis due to their contribution to innate immune responses and amyloid beta (Ab) clearance mechanisms. Methods: Blood-derived monocytes (BDMs) and monocyte-derived macrophages (MDMs) were isolated from blood of AD, mild cognitive impairment (MCI) patients, and age-matched healthy controls for molecular and phenotypic comparisons. Results: The chemokine/chemokine receptor CCL2/CCR2 axis was impaired in BDMs fromAD and MCI patients, causing a deficit in cell migration. Changes were also observed in MDM-mediated phagocytosis of Ab fibrils, correlating with alterations in the expression and processing of the triggering receptor expressed on myeloid cells 2 (TREM2). Finally, immune-related microRNAs (miRNAs), including miR-155, -154, -200b, -27b, and -128, were found to be differentially expressed in these cells. Discussion: This work provides evidence that chemotaxis and phagocytosis, two crucial innate immune functions, are impaired in AD and MCI patients. Correlations with miRNA levels suggest an epigenetic contribution to systemic immune dysfunction in AD.pt
dc.language.isoengpt
dc.publisherElsevierpt
dc.relationSFRH/BD/ 51677/2011pt
dc.relationSFRH/BPD/99613/2014pt
dc.relationPTDC/ BIM-MEC/0651/2012pt
dc.relationFEDER/COMPETE (PEst-C/ SAU/LA0001/2013-2014)pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectAlzheimer’s diseasept
dc.subjectMonocytespt
dc.subjectMacrophagespt
dc.subjectChemotaxispt
dc.subjectPhagocytosispt
dc.subjectCCR2pt
dc.subjectTREM2pt
dc.subjectmiRNAspt
dc.titleMicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's diseasept
dc.typearticle-
degois.publication.firstPage7pt
degois.publication.lastPage17pt
degois.publication.issue1pt
degois.publication.titleAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoringpt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.dadm.2015.11.004pt
degois.publication.volume3pt
dc.date.embargo2016-01-01*
uc.date.periodoEmbargo0pt
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCenter for Research in Neuropsychology and Cognitive Behavioral Intervention (CINEICC)-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Psychology and Educational Sciences-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-8114-9434-
crisitem.author.orcid0000-0002-9818-9862-
crisitem.author.orcid0000-0002-1889-5469-
crisitem.author.orcid0000-0003-1844-5027-
crisitem.author.orcid0000-0003-0551-7255-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons