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Title: Vitamin D and Age-Related Macular Degeneration
Authors: Layana, Alfredo Garcia
Minnella, Angelo Maria
Garhöfer, Gerhard
Aslam, Tariq
Holz, Frank G
Leys, Anita
Silva, Rufino 
Delcourt, Cécile
Souied, Eric
Seddon, Johanna M.
Keywords: vitamin D; age-related macular degeneration; inflammation; angiogenesis
Issue Date: 13-Oct-2017
Publisher: MDPI
Project: Laboratoires Théa, France 
Serial title, monograph or event: Nutrients
Volume: 9
Issue: 10
Abstract: In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.
ISSN: 2072-6643
DOI: 10.3390/nu9101120
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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