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Title: Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases
Authors: Madeira, Maria H. 
Boia, Raquel 
Ambrósio, António F. 
Santiago, Ana R. 
Issue Date: 2017
Publisher: Hindawi
Project: PD/BD/114115/2015 
PEst-C/ SAU/UI3282/2013 
Manuel Rui Azinhais Nabeiro Lda 
grant from the Global Ophthalmology Awards Program from Bayer HealthCare 
Serial title, monograph or event: Mediators of Inflammation
Volume: 2017
Abstract: Caffeine is the major component of coffee and the most consumed psychostimulant in the world and at nontoxic doses acts as a nonselective adenosine receptor antagonist. Epidemiological evidence suggests that caffeine consumption reduces the risk of several neurological and neurodegenerative diseases. However, despite the beneficial effects of caffeine consumption in human health and behaviour, the mechanisms by which it impacts the pathophysiology of neurodegenerative diseases still remain to be clarified. A promising hypothesis is that caffeine controls microglia-mediated neuroinflammatory response associated with the majority of neurodegenerative conditions. Accordingly, it has been already described that the modulation of adenosine receptors, namely, the A2A receptor, affords neuroprotection through the control of microglia reactivity and neuroinflammation. In this review, we will summarize the main effects of caffeine in the modulation of neuroinflammation in neurodegenerative diseases.
ISSN: 0962-9351
DOI: 10.1155/2017/4761081
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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