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https://hdl.handle.net/10316/108125
Title: | The Lifespan and Turnover of Microglia in the Human Brain | Authors: | Réu, Pedro Khosravi, Azadeh Bernard, Samuel Mold, Jeff E Salehpour, Mehran Alkass, Kanar Perl, Shira Tisdale, John Possnert, Göran Druid, Henrik Frisén, Jonas |
Keywords: | human; microglia; proliferation; renewal; turnover | Issue Date: | 25-Jul-2017 | Publisher: | Elsevier | Project: | grants from the Swedish Research Council, the Swedish Cancer Society, the Karolinska Institute, Tobias Stiftelsen, the ERC, Knut och Alice Wallenbergs Stiftelse, and Torsten So¨ derbergs Stiftelse FCT - grant SFRH/BD/33465/2008 |
Serial title, monograph or event: | Cell Reports | Volume: | 20 | Issue: | 4 | Abstract: | The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglia last for more than two decades. Furthermore, we find no evidence for the existence of a substantial population of quiescent long-lived cells, meaning that the microglia population in the human brain is sustained by continuous slow turnover throughout adult life. | URI: | https://hdl.handle.net/10316/108125 | ISSN: | 22111247 | DOI: | 10.1016/j.celrep.2017.07.004 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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The Lifespan and Turnover of Microglia in the Human Brain.pdf | 1.3 MB | Adobe PDF | View/Open |
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