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Title: Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors
Authors: Basso, João 
Miranda, Ana 
Nunes, Sandra 
Cova, Tânia 
Sousa, João 
Vitorino, Carla 
Pais, Alberto 
Keywords: hydrogel; nanostructured drug delivery system; hydrogel nanoparticles; glioblastoma; drug delivery; local treatment
Issue Date: 19-Jul-2018
Publisher: MDPI
Project: This paper was financially supported by the Fundação para a Ciência e a Tecnologia (FCT), Portuguese Agency for Scientific Research, through: the project no. 016648 (Ref. POCI-01-0145-FEDER-016648), the project PEst-UID/NEU/04539/2013, and COMPETE (Ref. POCI-01-0145-FEDER-007440)-Center for Neurosciences and Cell Biology (CNC); the projects PEst-OE/QUI/UI0313/2014 and POCI-01-0145-FEDER-007630-Coimbra Chemistry Centre; and the project UID/QUI/50006/2013-LAQV/REQUIMTE. Tânia Cova acknowledges the PhD research grant SFRH/BD/95459/2013, assigned by FCT. 
Serial title, monograph or event: Gels
Volume: 4
Issue: 3
Abstract: Chemotherapy is commonly associated with limited effectiveness and unwanted side effects in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells when systemically administered. In brain tumors, the existence of both physiological barriers that protect tumor cells and complex resistance mechanisms to anticancer drugs are additional obstacles that hamper a successful course of chemotherapy, thus resulting in high treatment failure rates. Several potential surrogate therapies have been developed so far. In this context, hydrogel-based systems incorporating nanostructured drug delivery systems (DDS) and hydrogel nanoparticles, also denoted nanogels, have arisen as a more effective and safer strategy than conventional chemotherapeutic regimens. The former, as a local delivery approach, have the ability to confine the release of anticancer drugs near tumor cells over a long period of time, without compromising healthy cells and tissues. Yet, the latter may be systemically administered and provide both loading and targeting properties in their own framework, thus identifying and efficiently killing tumor cells. Overall, this review focuses on the application of hydrogel matrices containing nanostructured DDS and hydrogel nanoparticles as potential and promising strategies for the treatment and diagnosis of glioblastoma and other types of brain cancer. Some aspects pertaining to computational studies are finally addressed.
ISSN: 2310-2861
DOI: 10.3390/gels4030062
Rights: openAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

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