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Title: | First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal | Authors: | Caneiras, Cátia Calisto, Filipa Silva, Gabriela Jorge da Lito, Luis Melo-Cristino, José Duarte, Aida |
Keywords: | antimicrobial resistance; Gram-negative bacteria; K. pneumoniae; A. baumannii; KPC-3 carbapenemase; colistin; tigecycline | Issue Date: | 6-Nov-2018 | Publisher: | MDPI | Project: | Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon | Serial title, monograph or event: | Antibiotics | Volume: | 7 | Issue: | 4 | Abstract: | Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin. | URI: | https://hdl.handle.net/10316/107492 | ISSN: | 2079-6382 | DOI: | 10.3390/antibiotics7040096 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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