Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107492
Title: | First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal | Authors: | Caneiras, Cátia Calisto, Filipa Silva, Gabriela Jorge da Lito, Luis Melo-Cristino, José Duarte, Aida |
Keywords: | antimicrobial resistance; Gram-negative bacteria; K. pneumoniae; A. baumannii; KPC-3 carbapenemase; colistin; tigecycline | Issue Date: | 6-Nov-2018 | Publisher: | MDPI | Project: | Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon | Serial title, monograph or event: | Antibiotics | Volume: | 7 | Issue: | 4 | Abstract: | Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin. | URI: | https://hdl.handle.net/10316/107492 | ISSN: | 2079-6382 | DOI: | 10.3390/antibiotics7040096 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
First-description-of-colistin-and-tigecyclineresistant-acinetobacter-baumannii-producing-KPC3-carbapenemase-in-PortugalAntibiotics.pdf | 285.85 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
26
checked on Sep 30, 2024
WEB OF SCIENCETM
Citations
24
checked on Oct 2, 2024
Page view(s)
75
checked on Oct 8, 2024
Download(s)
17
checked on Oct 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License