Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107486
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baldeiras, Inês | - |
dc.contributor.author | Santana, Isabel | - |
dc.contributor.author | Leitão, Maria João | - |
dc.contributor.author | Gens, Helena | - |
dc.contributor.author | Pascoal, Rui | - |
dc.contributor.author | Tábuas-Pereira, Miguel | - |
dc.contributor.author | Beato-Coelho, José | - |
dc.contributor.author | Duro, Diana | - |
dc.contributor.author | Almeida, Maria do Rosário | - |
dc.contributor.author | Oliveira, Catarina Resende de | - |
dc.date.accessioned | 2023-07-14T10:07:38Z | - |
dc.date.available | 2023-07-14T10:07:38Z | - |
dc.date.issued | 2018-03-20 | - |
dc.identifier.issn | 1758-9193 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/107486 | - |
dc.description.abstract | Background: Cerebrospinal fluid (CSF) biomarkers have been used to increase the evidence of underlying Alzheimer’s disease (AD) pathology in mild cognitive impairment (MCI). However, CSF biomarker-based classification often results in conflicting profiles with controversial prognostic value. Normalization of the CSF Aβ42 concentration to the level of total amyloid beta (Aβ), using the Aβ42/40 ratio, has been shown to improve the distinction between AD and non-AD dementia. Therefore, we evaluated whether the Aβ42/40 ratio would improve MCI categorization and more accurately predict progression to AD. Methods: Our baseline population consisted of 197 MCI patients, of which 144 had a follow-up ≥ 2 years, and comprised the longitudinal study group. To establish our own CSF Aβ42/40 ratio reference value, a group of 168 AD-dementia patients and 66 neurological controls was also included. CSF biomarker-based classification was operationalized according to the framework of the National Institute of Aging–Alzheimer Association criteria for MCI. Results: When using the core CSF biomarkers (Aβ42, total Tau and phosphorylated Tau), 30% of the patients fell into the high-AD-likelihood (HL) group (both amyloid and neurodegeneration markers positive), 30% into the low-AD-likelihood group (all biomarkers negative), 28% into the suspected non-Alzheimer pathophysiology (SNAP) group (only neurodegeneration markers positive) and 12% into the isolated amyloid pathology group (only amyloid-positive). Replacing Aβ42 by the Aβ42/40 ratio resulted in a significant increase in the percentage of patients with amyloidosis (42–59%) and in the proportion of interpretable biological profiles (61–75%), due to a reduction by half in the number of SNAP cases and an increase in the proportion of the HL subgroup. Survival analysis showed that risk of progression to AD was highest in the HL group, and increased when the Aβ42/40 ratio, instead of Aβ42, combined with total Tau and phosphorylated Tau was used for biomarker-based categorization. Conclusions: Our results confirm the usefulness of the CSF Aβ42/40 ratio in the interpretation of CSF biomarker profiles in MCI patients, by increasing the proportion of conclusive profiles and enhancing their predictive value for underlying AD. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | FCT - PD/BD/135108/2017 | pt |
dc.relation | FCT - SFRH/BD/52289/ 2013 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Alzheimer’s disease | pt |
dc.subject | Aβ42/40 ratio | pt |
dc.subject | CSF biomarkers | pt |
dc.subject | Mild cognitive impairment | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Aged, 80 and over | pt |
dc.subject.mesh | Alzheimer Disease | pt |
dc.subject.mesh | Amyloid beta-Peptides | pt |
dc.subject.mesh | Cognitive Dysfunction | pt |
dc.subject.mesh | Disease Progression | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Longitudinal Studies | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Peptide Fragments | pt |
dc.subject.mesh | Psychiatric Status Rating Scales | pt |
dc.subject.mesh | Survival Analysis | pt |
dc.subject.mesh | tau Proteins | pt |
dc.title | Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive impairment | pt |
dc.type | article | - |
degois.publication.firstPage | 33 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Alzheimer's Research and Therapy | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/s13195-018-0362-2 | pt |
degois.publication.volume | 10 | pt |
dc.date.embargo | 2018-03-20 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | Center for Research in Neuropsychology and Cognitive Behavioral Intervention | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-8106-7308 | - |
crisitem.author.orcid | 0000-0002-8114-9434 | - |
crisitem.author.orcid | 0000-0002-8950-1439 | - |
crisitem.author.orcid | 0000-0002-9818-9862 | - |
crisitem.author.orcid | 0000-0002-1889-5469 | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
SCOPUSTM
Citations
63
checked on May 6, 2024
WEB OF SCIENCETM
Citations
57
checked on May 2, 2024
Page view(s)
61
checked on May 7, 2024
Download(s)
17
checked on May 7, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License