Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107438
Title: Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
Authors: Alves, Nuno Guerreiro 
Alves, Américo J. S. 
Soares, Maria I. L. 
Pinho e Melo, Teresa M. V. D. 
Keywords: β-lactams; δ-lactams; spiro-β-lactams; spiro-δ-lactams; penicillanates; spirocyclization
Issue Date: 2021
Publisher: Wiley Online Library
Project: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/00313/2020/PT/Coimbra Chemistry Center 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP/00313/2020/PT/Coimbra Chemistry Center 
info:eu-repo/grantAgreement/FCT/POR_CENTRO/PD/BD/135287/2017/PT/Broadening the spectrum of spito-B-lactams antiviral activity: from new targets identification to the discovery of new compounds with anti-influenza activity. 
info:eu-repo/grantAgreement/FCT/OE/SFRH/BD/128910/2017/PT/Novel spiro-lactams as new antimicrobial agents 
Serial title, monograph or event: Advanced Synthesis & Catalysis
Volume: 363
Issue: 10
Abstract: Spirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been engaged on the pursuit of new synthetic strategies towards these molecules. The present review gathers advances on the synthesis of both spiro- β-lactams (spiroazetidin-2-ones) and spiro-δ-lactams (spiropiperidon-2-ones) reported since 2015. The work is divided into two distinct parts, each one dedicated to one of these types of spiro-lactam, with the approach used for building the spirocyclic system being extensively discussed, according to the method’s scope, efficiency, selectivity, and reaction mechanism.
URI: https://hdl.handle.net/10316/107438
ISSN: 1615-4150
1615-4169
DOI: 10.1002/adsc.202100013
Rights: embargoedAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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