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Title: Lipoxidation and cancer immunity
Authors: Martín-Sierra, C. 
Laranjeira, P. 
Domingues, M. R. M. 
Paiva, A. 
Keywords: Lipoxidation; Protein adducts; Cancer; Immune system
Issue Date: May-2019
Publisher: Elsevier
Project: We acknowledge the European Commission's Horizon 2020 research and innovation programme for the Marie Sklodowska-Curie grant agreement number 675132 (MSCA-ITN-ETN MASSTRPLAN) to University of Aveiro and to Centro Hospitalar e Universitário de Coimbra. Thanks are due to the University of Aveiro, FCT/MEC, European Union, QREN, COMPETE for the financial support to the QOPNA (FCT UID/QUI/00062/2013) and CESAM (UID/AMB/50017 - POCI-01–0145-FEDER-007638), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement, to the Portuguese Mass Spectrometry Network (LISBOA- 01–0145-FEDER-402–022125). 
Serial title, monograph or event: Redox Biology
Volume: 23
Abstract: Lipoxidation is a well-known reaction between electrophilic carbonyl species, formed during oxidation of lipids, and specific proteins that, in most cases, causes an alteration in proteins function. This can occur under physiological conditions but, in many cases, it has been associated to pathological process, including cancer. Lipoxidation may have an effect in cancer development through their effects in tumour cells, as well as through the alteration of immune components and the consequent modulation of the immune response. The formation of protein adducts affects different proteins in cancer, triggering different mechanism, such as proliferation, cell differentiation and apoptosis, among others, altering cancer progression. The divergent results obtained documented that the formation of lipoxidation adducts can have either anti-carcinogenic or pro-carcinogenic effects, depending on the cell type affected and the specific adduct formed. Moreover, lipoxidation adducts may alter the immune response, consequently causing either positive or negative alterations in cancer progression. Therefore, in this review, we summarize the effects of lipoxidation adducts in cancer cells and immune components and their consequences in the evolution of different types of cancer.
ISSN: 22132317
DOI: 10.1016/j.redox.2019.101103
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais

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