Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107323
Title: | Lipoxidation and cancer immunity | Authors: | Martín-Sierra, C. Laranjeira, P. Domingues, M. R. M. Paiva, A. |
Keywords: | Lipoxidation; Protein adducts; Cancer; Immune system | Issue Date: | May-2019 | Publisher: | Elsevier | Project: | We acknowledge the European Commission's Horizon 2020 research and innovation programme for the Marie Sklodowska-Curie grant agreement number 675132 (MSCA-ITN-ETN MASSTRPLAN) to University of Aveiro and to Centro Hospitalar e Universitário de Coimbra. Thanks are due to the University of Aveiro, FCT/MEC, European Union, QREN, COMPETE for the financial support to the QOPNA (FCT UID/QUI/00062/2013) and CESAM (UID/AMB/50017 - POCI-01–0145-FEDER-007638), through national funds and where applicable co-financed by the FEDER, within the PT2020 Partnership Agreement, to the Portuguese Mass Spectrometry Network (LISBOA- 01–0145-FEDER-402–022125). | Serial title, monograph or event: | Redox Biology | Volume: | 23 | Abstract: | Lipoxidation is a well-known reaction between electrophilic carbonyl species, formed during oxidation of lipids, and specific proteins that, in most cases, causes an alteration in proteins function. This can occur under physiological conditions but, in many cases, it has been associated to pathological process, including cancer. Lipoxidation may have an effect in cancer development through their effects in tumour cells, as well as through the alteration of immune components and the consequent modulation of the immune response. The formation of protein adducts affects different proteins in cancer, triggering different mechanism, such as proliferation, cell differentiation and apoptosis, among others, altering cancer progression. The divergent results obtained documented that the formation of lipoxidation adducts can have either anti-carcinogenic or pro-carcinogenic effects, depending on the cell type affected and the specific adduct formed. Moreover, lipoxidation adducts may alter the immune response, consequently causing either positive or negative alterations in cancer progression. Therefore, in this review, we summarize the effects of lipoxidation adducts in cancer cells and immune components and their consequences in the evolution of different types of cancer. | URI: | https://hdl.handle.net/10316/107323 | ISSN: | 22132317 | DOI: | 10.1016/j.redox.2019.101103 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Lipoxidation and cancer immunity.pdf | 2.27 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
18
checked on Apr 15, 2024
WEB OF SCIENCETM
Citations
17
checked on Apr 2, 2024
Page view(s)
48
checked on Apr 23, 2024
Download(s)
16
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License