Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107126
Title: Liver Metastases and Histological Growth Patterns: Biological Behavior and Potential Clinical Implications-Another Path to Individualized Medicine?
Authors: Oliveira, Rui Caetano 
Alexandrino, Henrique 
Cipriano, Maria Augusta 
Tralhão, José Guilherme 
Issue Date: 2019
Publisher: Hindawi
metadata.degois.publication.title: Journal of Oncology
metadata.degois.publication.volume: 2019
Abstract: Colorectal cancer is a major health burden and despite the recent advances in healthcare and screening programs, a great percentage of patients already present metastases once their disease is found. In those cases, liver surgery has an essential role, but even with neoadjuvant chemotherapy there is a high rate of intrahepatic recurrence. New prognostic factors are needed in order to decide the best surgical approach considering the biological behavior of the tumors in order to tailor the used therapies, moving towards individualized medicine/treatment. However, the majority of the factors described in literature are expensive, time consuming, and difficult to apply on a daily basis. Histological growth patterns have emerged over the past few years as a reproducible characteristic, an easy to apply one, and with very low costs since it only needs the standard Haematoxylin and Eosin stained slides of observation. In this article, we provide a review of the histological growth patterns of liver metastases and their prognostic significance, biological meaning, and therapeutic importance.
URI: https://hdl.handle.net/10316/107126
ISSN: 1687-8450
DOI: 10.1155/2019/6280347
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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