Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107037
Title: Murine Models of Acute Pancreatitis: A Critical Appraisal of Clinical Relevance
Authors: Silva-Vaz, Pedro
Abrantes, Ana Margarida 
Gouveia, António
Botelho, Maria Filomena 
Tralhão, José Guilherme 
Castelo-Branco, Miguel 
Keywords: acute pancreatitis; animalmodels; murine; experimentalmodels; biomarkers; inflammation
Issue Date: 7-Jun-2019
Publisher: MDPI
Project: PEst-C/SAU/UI3282/2013 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 20
Issue: 11
Abstract: Acute pancreatitis (AP) is a severe disease associated with high morbidity and mortality. Clinical studies can provide some data concerning the etiology, pathophysiology, and outcomes of this disease. However, the study of early events and new targeted therapies cannot be performed on humans due to ethical reasons. Experimental murine models can be used in the understanding of the pancreatic inflammation, because they are able to closely mimic the main features of human AP, namely their histologic glandular changes and distant organ failure. These models continue to be important research tools for the reproduction of the etiological, environmental, and genetic factors associated with the pathogenesis of this inflammatory pathology and the exploration of novel therapeutic options. This review provides an overview of several murine models of AP. Furthermore, special focus is made on the most frequently carried out models, the protocols used, and their advantages and limitations. Finally, examples are provided of the use of these models to improve knowledge of the mechanisms involved in the pathogenesis, identify new biomarkers of severity, and develop new targeted therapies.
URI: https://hdl.handle.net/10316/107037
ISSN: 1422-0067
DOI: 10.3390/ijms20112794
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais

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