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https://hdl.handle.net/10316/107037
Title: | Murine Models of Acute Pancreatitis: A Critical Appraisal of Clinical Relevance | Authors: | Silva-Vaz, Pedro Abrantes, Ana Margarida Gouveia, António Botelho, Maria Filomena Tralhão, José Guilherme Castelo-Branco, Miguel |
Keywords: | acute pancreatitis; animalmodels; murine; experimentalmodels; biomarkers; inflammation | Issue Date: | 7-Jun-2019 | Publisher: | MDPI | Project: | PEst-C/SAU/UI3282/2013 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT |
Serial title, monograph or event: | International Journal of Molecular Sciences | Volume: | 20 | Issue: | 11 | Abstract: | Acute pancreatitis (AP) is a severe disease associated with high morbidity and mortality. Clinical studies can provide some data concerning the etiology, pathophysiology, and outcomes of this disease. However, the study of early events and new targeted therapies cannot be performed on humans due to ethical reasons. Experimental murine models can be used in the understanding of the pancreatic inflammation, because they are able to closely mimic the main features of human AP, namely their histologic glandular changes and distant organ failure. These models continue to be important research tools for the reproduction of the etiological, environmental, and genetic factors associated with the pathogenesis of this inflammatory pathology and the exploration of novel therapeutic options. This review provides an overview of several murine models of AP. Furthermore, special focus is made on the most frequently carried out models, the protocols used, and their advantages and limitations. Finally, examples are provided of the use of these models to improve knowledge of the mechanisms involved in the pathogenesis, identify new biomarkers of severity, and develop new targeted therapies. | URI: | https://hdl.handle.net/10316/107037 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms20112794 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais |
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