Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106736
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dc.contributor.authorCristovão, Gonçalo-
dc.contributor.authorMilner, James-
dc.contributor.authorSousa, Pedro-
dc.contributor.authorVentura, Miguel-
dc.contributor.authorCristóvão, João-
dc.contributor.authorElvas, Luís-
dc.contributor.authorPaiva, Artur-
dc.contributor.authorGonçalves, Lino-
dc.contributor.authorRibeiro, Carlos Fontes-
dc.contributor.authorAntónio, Natália-
dc.date.accessioned2023-04-20T09:19:33Z-
dc.date.available2023-04-20T09:19:33Z-
dc.date.issued2020-05-24-
dc.identifier.issn1757-6512pt
dc.identifier.urihttps://hdl.handle.net/10316/106736-
dc.description.abstractBackground: Recent studies suggest that circulating endothelial progenitor cells (EPCs) may influence the response to cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the effect of CRT on EPC levels and to assess the impact of EPCs on long-term clinical outcomes. Population and methods: Prospective study of 50 patients submitted to CRT. Two populations of circulating EPCs were quantified previously to CRT implantation: CD34+KDR+ and CD133+KDR+ cells. EPC levels were reassessed 6 months after CRT. Endpoints during the long-term follow-up were all-cause mortality, heart transplantation, and hospitalization for heart failure (HF) management. Results: The proportion of non-responders to CRT was 42% and tended to be higher in patients with an ischemic vs non-ischemic etiology (64% vs 35%, p = 0.098). Patients with ischemic cardiomyopathy (ICM) showed significantly lower CD34+KDR+ EPC levels when compared to non-ischemic dilated cardiomyopathy patients (DCM) (0.0010 ± 0.0007 vs 0.0030 ± 0.0024 cells/100 leukocytes, p = 0.032). There were no significant differences in baseline EPC levels between survivors and non-survivors nor between patients who were rehospitalized for HF management during follow-up or not. At 6-month follow-up, circulating EPC levels were significantly higher than baseline levels (0.0024 ± 0.0023 vs 0.0047 ± 0.0041 CD34+KDR+ cells/100 leukocytes, p = 0.010 and 0.0007 ± 0.0004 vs 0.0016 vs 0.0013 CD133+/KDR+ cells/100 leukocytes, p = 0.007). Conclusions: Patients with ICM showed significantly lower levels of circulating EPCs when compared to their counterparts. CRT seems to improve the pool of endogenously circulating EPCs and reduced baseline EPC levels seem not to influence long-term outcomes after CRT.pt
dc.language.isoengpt
dc.publisherSpringer Naturept
dc.relationresearch grant from St Jude Medical and consulting fees from Boston Scientificpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectEndothelial progenitor cellspt
dc.subjectCardiac resynchronization therapypt
dc.subjectHeart failurept
dc.subjectPrognosispt
dc.subject.meshFlow Cytometrypt
dc.subject.meshHumanspt
dc.subject.meshProspective Studiespt
dc.subject.meshCardiac Resynchronization Therapypt
dc.subject.meshEndothelial Progenitor Cellspt
dc.subject.meshHeart Failurept
dc.titleImprovement in circulating endothelial progenitor cells pool after cardiac resynchronization therapy: increasing the list of benefitspt
dc.typearticle-
degois.publication.firstPage194pt
degois.publication.issue1pt
degois.publication.titleStem Cell Research and Therapypt
dc.peerreviewedyespt
dc.identifier.doi10.1186/s13287-020-01713-8pt
degois.publication.volume11pt
dc.date.embargo2020-05-24*
uc.date.periodoEmbargo0pt
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-6562-5859-
crisitem.author.orcid0000-0001-9255-3064-
crisitem.author.orcid0000-0002-9707-4895-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
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