Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106693
Title: Experimental Models as Refined Translational Tools for Breast Cancer Research
Authors: Costa, Eduardo 
Ferreira-Gonçalves, Tânia
Chasqueira, Gonçalo
Cabrita, António S. 
Figueiredo, Isabel V. 
Reis, Catarina Pinto 
Keywords: oncology; breast cancer; experimental models; animal models; in vitro; in silico; pharmacological testing; strategies of drug development
Issue Date: 2020
Publisher: MDPI
Project: UID/DTP/04138/2019 
UIDB/00313/2020 
SFRH/BD/147306/2019 
Serial title, monograph or event: Scientia Pharmaceutica
Volume: 88
Issue: 3
Abstract: Breast cancer is one of the most common cancers worldwide, which makes it a very impactful malignancy in the society. Breast cancers can be classified through di erent systems based on the main tumor features and gene, protein, and cell receptors expression, which will determine the most advisable therapeutic course and expected outcomes. Multiple therapeutic options have already been proposed and implemented for breast cancer treatment. Nonetheless, their use and e cacy still greatly depend on the tumor classification, and treatments are commonly associated with invasiveness, pain, discomfort, severe side e ects, and poor specificity. This has demanded an investment in the research of the mechanisms behind the disease progression, evolution, and associated risk factors, and on novel diagnostic and therapeutic techniques. However, advances in the understanding and assessment of breast cancer are dependent on the ability to mimic the properties and microenvironment of tumors in vivo, which can be achieved through experimentation on animal models. This review covers an overview of the main animal models used in breast cancer research, namely in vitro models, in vivo models, in silico models, and other models. For each model, the main characteristics, advantages, and challenges associated to their use are highlighted.
URI: https://hdl.handle.net/10316/106693
ISSN: 2218-0532
DOI: 10.3390/scipharm88030032
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Show full item record

SCOPUSTM   
Citations

15
checked on May 6, 2024

WEB OF SCIENCETM
Citations

11
checked on May 2, 2024

Page view(s)

52
checked on May 21, 2024

Download(s)

21
checked on May 21, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons