Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106539
Title: | Development and Characterization of Biointeractive Gelatin Wound Dressing Based on Extract of Punica granatum Linn | Authors: | do Nascimento, Marismar F. Cardoso, Juliana C. Santos, Tarsizio S. Tavares, Lívia A. Pashirova, Tatiana N. Severino, Patrícia Souto, Eliana B. Albuquerque-Junior, Ricardo L. C. de |
Keywords: | gallic acid; ellagic acid; gelatin; biological dressings; Punica granatum; wound healing | Issue Date: | 11-Dec-2020 | Publisher: | MDPI | Project: | FAPITEC/SE (Fundação de Apoio à Pesquisa e Inovação Tecnológica do Estado de Sergipe) and by the Brazilian Bureau of Research. T. Pashirova received the financial support from the government assignment for the FRC Kazan Scientific Center of Russian Academy of Sciences. E.B. Souto received the support from the projects M-ERA-NET-0004/2015-PAIRED and UIDB/04469/2020, granted by the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds and co-financed by FEDER under the Partnership Agreement PT2020. | Serial title, monograph or event: | Pharmaceutics | Volume: | 12 | Issue: | 12 | Abstract: | Punica granatum Linn (pomegranate) extracts have been proposed for wound healing due to their antimicrobial, antioxidant, and anti-inflammatory properties. In this work, we designed biointeractive membranes that contain standard extracts of P. granatum for the purpose of wound healing. The used standard extract contained 32.24 mg/g of gallic acid and 41.67 mg/g of ellagic acid, and it showed high antioxidant activity (the concentration of the extract that produces 50% scavenging (IC50) 1.715 µg/mL). Compared to the gelatin-based membranes (GEL), membranes containing P. granatum extracts (GELPG) presented a higher maximal tension (p = 0.021) and swelling index (p = 0.033) and lower water vapor permeability (p = 0.003). However, no difference was observed in the elongation and elastic modulus of the two types of membranes (p > 0.05). Our wound-healing assay showed that a GELPG-treated group experienced a significant increase compared to that of the control group in their wound contraction rates on days 3 (p < 0.01), 7 (p < 0.001), and on day 14 (p < 0.001). The GELPG membranes promoted major histological changes in the dynamics of wound healing, such as improvements in the formation of granular tissue, better collagen deposition and arrangement, and earlier development of cutaneous appendages. Our results suggest that a biointeractive gelatin-based membrane containing P. granatum extracts has a promising potential application for dressings that are used to treat wounds. | URI: | https://hdl.handle.net/10316/106539 | ISSN: | 1999-4923 | DOI: | 10.3390/pharmaceutics12121204 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Development-and-characterization-of-biointeractive-gelatin-wound-dressing-based-on-extract-of-Punica-granatum-linnPharmaceutics.pdf | 4.12 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
18
checked on Apr 22, 2024
WEB OF SCIENCETM
Citations
14
checked on Apr 2, 2024
Page view(s)
23
checked on Apr 23, 2024
Download(s)
22
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License