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Title: Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells
Authors: Calmeiro, João 
Carrascal, Mylène A. 
Tavares, Adriana Ramos 
Ferreira, Daniel Alexandre 
Gomes, Célia 
Falcão, Amílcar 
Cruz, Maria Teresa 
Neves, Bruno Miguel 
Keywords: conventional type 1 dendritic cells; CD141+XCR1+ DCs; dendritic cell-based vaccines; anti-tumor immunotherapy
Issue Date: 15-Feb-2020
Publisher: MDPI
Project: POCI-01-0247-FEDER-033532 
PhD fellowship (PD/BDE/135076/2017) 
Serial title, monograph or event: Pharmaceutics
Volume: 12
Issue: 2
Abstract: Throughout the last decades, dendritic cell (DC)-based anti-tumor vaccines have proven to be a safe therapeutic approach, although with inconsistent clinical results. The functional limitations of ex vivo monocyte-derived dendritic cells (MoDCs) commonly used in these therapies are one of the pointed explanations for their lack of robustness. Therefore, a great effort has been made to identify DC subsets with superior features for the establishment of effective anti-tumor responses and to apply them in therapeutic approaches. Among characterized human DC subpopulations, conventional type 1 DCs (cDC1) have emerged as a highly desirable tool for empowering anti-tumor immunity. This DC subset excels in its capacity to prime antigen-specific cytotoxic T cells and to activate natural killer (NK) and natural killer T (NKT) cells, which are critical factors for an effective anti-tumor immune response. Here, we sought to revise the immunobiology of cDC1 from their ontogeny to their development, regulation and heterogeneity. We also address the role of this functionally thrilling DC subset in anti-tumor immune responses and the most recent efforts to apply it in cancer immunotherapy.
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics12020158
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CIBIT - Artigos em Revistas Internacionais

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