Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106519
Title: Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet
Authors: Nunes, Sara 
Alves, André 
Preguiça, Inês 
Barbosa, Adelaide 
Vieira, Pedro 
Mendes, Fernando 
Martins, Diana 
Viana, Sofia D. 
Reis, Flávio 
Keywords: prediabetes; nephropathy; rat model; diet-induced; renal lipidosis; glomerular crescent-like lesions
Issue Date: 25-Mar-2020
Publisher: MDPI
Project: CENTRO-01-0145-FEDER-000012-HealthyAging2020 
UID/NEU/04539/2013 
UID/NEU/04539/2019 
UIDB/04539/2020 
UIDP/04539/2020 
info:eu-repo/grantAgreement/SFRH/BD/109017/2015 
PTDC/SAU-NUT/31712/2017 
POCI-01-0145-FEDER-007440 
POCI-01-0145-FEDER-031712 
Serial title, monograph or event: Nutrients
Volume: 12
Issue: 4
Abstract: Diabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly inefficient. This ambition greatly depends on the existence of accurate early biomarkers and novel molecular targets, which only may arise with a more thorough knowledge of disease pathophysiology. We used a rat model of prediabetes induced by 23 weeks of high-sugar/high-fat (HSuHF) diet to characterize the phenotype of early renal dysfunction and injury. When compared with the control animals, HSuHF-treated rats displayed a metabolic phenotype compatible with obese prediabetes, displaying impaired glucose tolerance and insulin sensitivity, along with hypertriglyceridemia, and lipid peroxidation. Despite unchanged creatinine levels, the prediabetic animals presented glomerular crescent-like lesions, accompanied by increased kidney Oil-Red-O staining, triglycerides content and mRNA expression of IL-6 and iNOS. This model of HSuHF-induced prediabetes can be a useful tool to study early features of DN, namely crescent-like lesions, an early signature that deserves in-depth elucidation.
URI: https://hdl.handle.net/10316/106519
ISSN: 2072-6643
DOI: 10.3390/nu12040881
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais

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