Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106496
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Abu-Darwish, Mohammad Sanad | - |
dc.contributor.author | Cabral, Célia | - |
dc.contributor.author | Ali, Zulfigar | - |
dc.contributor.author | Wang, Mei | - |
dc.contributor.author | Khan, Shabana I. | - |
dc.contributor.author | Jacob, Melissa R. | - |
dc.contributor.author | Jain, Surendra K. | - |
dc.contributor.author | Tekwani, Babu L. | - |
dc.contributor.author | Zulfiqar, Fazila | - |
dc.contributor.author | Khan, Ikhlas A. | - |
dc.contributor.author | Taifour, Hatem | - |
dc.contributor.author | Salgueiro, Lígia | - |
dc.contributor.author | Efferth, Thomas | - |
dc.date.accessioned | 2023-04-05T10:12:40Z | - |
dc.date.available | 2023-04-05T10:12:40Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 2192-2195 | - |
dc.identifier.uri | https://hdl.handle.net/10316/106496 | - |
dc.description.abstract | In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC50 90 µg/mL) and NF-κB activity (IC50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development. | pt |
dc.description.sponsorship | This work has been conducted during the Fulbright visiting scholarship awarded to Prof. Dr. Mohammad Sanad Abu-Darwish during his Sabbatical leave from Al-Balqa’ Applied University, Al-Salt, Jordan, at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, USA. The authors thank the Dean of Scientific Research, Al-Balqa Applied University, Jordan, the Binational Fulbright Commission in Jordan, Council for International Exchange of Scholars (CIES), and Institute of International Education (IIE), USA. This work was also supported by Foundation for Science and Technology (FCT), Portugal (Strategic Projects UID/NEU/04539/2013 ,and UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/04539/2020 (CIBB)). | - |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Lamiaceae | pt |
dc.subject | Essential oil | pt |
dc.subject | Chemical composition | pt |
dc.subject | Cytotoxicity | pt |
dc.subject | Anti-inflammatory activity | pt |
dc.subject | Neglected diseases | pt |
dc.title | Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities | pt |
dc.type | article | pt |
degois.publication.firstPage | 307 | pt |
degois.publication.lastPage | 316 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Natural Products and Bioprospecting | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1007/s13659-020-00259-9 | - |
degois.publication.volume | 10 | pt |
dc.date.embargo | 2020-10-01 | * |
dc.identifier.pmid | 32852722 | - |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-4562-6683 | - |
crisitem.author.orcid | 0000-0003-0948-821X | - |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Salvia-ceratophylla-L-from-South-of-Jordan-new-insights-on-chemical-composition-and-biological-activitiesNatural-Products-and-Bioprospecting.pdf | 795.44 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
6
checked on Apr 29, 2024
WEB OF SCIENCETM
Citations
7
checked on May 2, 2024
Page view(s)
58
checked on May 8, 2024
Download(s)
16
checked on May 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License