Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106469
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dc.contributor.authorGomes, Ana T. P. C.-
dc.contributor.authorFernandes, Rosa-
dc.contributor.authorRibeiro, Carlos F. M.-
dc.contributor.authorTomé, João P. C.-
dc.contributor.authorNeves, Maria G. P. M. S.-
dc.contributor.authorSilva, Fernando de C. da-
dc.contributor.authorFerreira, Vítor F.-
dc.contributor.authorCavaleiro, José A. S.-
dc.date.accessioned2023-04-04T10:54:48Z-
dc.date.available2023-04-04T10:54:48Z-
dc.date.issued2020-03-31-
dc.identifier.issn1420-3049-
dc.identifier.urihttps://hdl.handle.net/10316/106469-
dc.description.abstractNovel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.pt
dc.description.sponsorshipThe authors are grateful to University of Aveiro and FCT/MCT for the financial support for QOPNA research Unit (FCT UID/QUI/00062/2019) and LAQV-REQUIMTE (UIDB/50006/2020) through national funds. Thanks are also due to FCT/MCT for the financial support of iCBR and CIBB units (TDC/QEQQOR/1273/2012; UID/NEU/04539/2019 FCT UID/QUI/00062/2013) and CQE unit (UIDB/00100/2020), COMPETE-FEDER (POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme: HEALTHYAGING 2020 (CENTRO-01-0145-FEDER-000012) for funding. Ana Gomes also thanks FCT for the post-doctoral grant (SFRH/BPD/79521/2011).-
dc.language.isoengpt
dc.publisherMDPIpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectporphyrinpt
dc.subjecttriazolept
dc.subjectpolyvinylpyrrolidonept
dc.subjectphotodynamic therapypt
dc.subjecthuman bladder cancer cellspt
dc.subjecthuman retinal pigment epithelial cellspt
dc.titleSynthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivativespt
dc.typearticlept
degois.publication.firstPage1607pt
degois.publication.issue7pt
degois.publication.titleMoleculespt
dc.peerreviewedyespt
dc.identifier.doi10.3390/molecules25071607-
degois.publication.volume25pt
dc.date.embargo2020-03-31*
dc.identifier.pmid32244514-
uc.date.periodoEmbargo0pt
dc.identifier.eissn1420-3049-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-7828-2296-
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
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