Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106452
DC Field | Value | Language |
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dc.contributor.author | Jun, Se-Ran | - |
dc.contributor.author | Cheema, Amrita | - |
dc.contributor.author | Bose, Chhanda | - |
dc.contributor.author | Boerma, Marjan | - |
dc.contributor.author | Palade, Philip T. | - |
dc.contributor.author | Carvalho, Eugenia | - |
dc.contributor.author | Awasthi, Sanjay | - |
dc.contributor.author | Singh, Sharda P. | - |
dc.date.accessioned | 2023-04-03T11:59:46Z | - |
dc.date.available | 2023-04-03T11:59:46Z | - |
dc.date.issued | 2020-09-29 | - |
dc.identifier.issn | 2076-2607 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/106452 | - |
dc.description.abstract | Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6-8 weeks) and old (21-22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled the microbiome and metabolome. Multi-omics datasets were analyzed individually and integrated to investigate the relationship between SFN diet, the gut microbiome, and metabolome. The SFN diet restored the gut microbiome in old mice to mimic that in young mice, enriching bacteria known to be associated with an improved intestinal barrier function and the production of anti-inflammatory compounds. The tricarboxylic acid cycle decreased and amino acid metabolism-related pathways increased. Integration of multi-omic datasets revealed SFN diet-induced metabolite biomarkers in old mice associated principally with the genera, Oscillospira, Ruminococcus, and Allobaculum. Collectively, our results support a hypothesis that SFN diet exerts anti-aging effects in part by influencing the gut microbiome and metabolome. Modulating the gut microbiome by SFN may have the potential to promote healthier aging. | pt |
dc.description.sponsorship | This work was supported in part by a grant fromthe National Institutes of Health (R01 AG032643), a grant from the American Heart Association (14GRNT18890084), and through an Institutional DevelopmentAward (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (www.nigms.nih.gov) under grant number P20 GM109005. Part of this research was supported by the Arkansas High Performance Computing Center which is funded through multiple National Science Foundation grants and the Arkansas Economic Development Commission. Part of this research was supported by UIDB/04539/2020 and P20GM109096. The authors would like to acknowledge the Metabolomics Shared Resource at Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008. Part of this research was-based upon work supported by the National Science Foundation under Award No. OIA-1946391. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. | - |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | aging | pt |
dc.subject | sulforaphane | pt |
dc.subject | gut microbiome | pt |
dc.subject | metabolome | pt |
dc.subject | biomarkers | pt |
dc.title | Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice | pt |
dc.type | article | - |
degois.publication.firstPage | 1500 | pt |
degois.publication.issue | 10 | pt |
degois.publication.title | Microorganisms | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/microorganisms8101500 | pt |
degois.publication.volume | 8 | pt |
dc.date.embargo | 2020-09-29 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.orcid | 0000-0001-6264-3632 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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Multiomic-analysis-reveals-different-effects-of-sulforaphane-on-the-microbiome-and-metabolome-in-old-compared-to-young-miceMicroorganisms.pdf | 4.91 MB | Adobe PDF | View/Open |
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