Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/10627
Title: DNA Gel Particles: Particle Preparation and Release Characteristics
Authors: Morán, M. Carmen 
Miguel, M. Graça 
Lindman, Björn 
Issue Date: 5-Jun-2007
Publisher: American Chemical Society
Citation: Langmuir. 23:12 (2007) 6478-6481
Abstract: Aqueous mixtures of oppositely charged polyelectrolytes undergo associative phase separation, resulting in coacervation, gelation, or precipitation. This phenomenon has been exploited here to form DNA gel particles by interfacial diffusion. We report the formation of DNA gel particles by mixing solutions of DNA (either single-stranded (ssDNA) or double-stranded (dsDNA)) with solutions of cationic surfactant CTAB and solutions of the protein lysozyme. Swelling, surface morphology, and DNA release determinations indicate different interaction of ssDNA and dsDNA with both the surfactant and the protein. By using CTAB and lysozyme as the base material, the formation of a DNA reservoir hydrogel, without adding any kind of cross-linker or organic solvent, was demostrated.
URI: http://hdl.handle.net/10316/10627
ISSN: 0743-7463
DOI: 10.1021/la700672e
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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