Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106196
Title: Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice
Authors: Silva-Vaz, Pedro
Abrantes, Ana Margarida 
Castelo-Branco, Miguel 
Gouveia, António
Botelho, Maria Filomena 
Tralhão, José Guilherme 
Keywords: acute pancreatitis; severity; prognostic; multifactorial scoring system; biomarker
Issue Date: 4-Jan-2020
Publisher: MDPI
Project: PEst-C/SAU/UI3282/2013 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 21
Issue: 1
Abstract: Acute pancreatitis (AP) is a severe inflammation of the pancreas presented with sudden onset and severe abdominal pain with a high morbidity and mortality rate, if accompanied by severe local and systemic complications. Numerous studies have been published about the pathogenesis of AP; however, the precise mechanism behind this pathology remains unclear. Extensive research conducted over the last decades has demonstrated that the first 24 h after symptom onset are critical for the identification of patients who are at risk of developing complications or death. The identification of these subgroups of patients is crucial in order to start an aggressive approach to prevent mortality. In this sense and to avoid unnecessary overtreatment, thereby reducing the financial implications, the proper identification of mild disease is also important and necessary. A large number of multifactorial scoring systems and biochemical markers are described to predict the severity. Despite recent progress in understanding the pathophysiology of AP, more research is needed to enable a faster and more accurate prediction of severe AP. This review provides an overview of the available multifactorial scoring systems and biochemical markers for predicting severe AP with a special focus on their advantages and limitations.
URI: https://hdl.handle.net/10316/106196
ISSN: 1422-0067
DOI: 10.3390/ijms21010338
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais

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