Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106187
Title: Brief Report on Double-Chamber Syringes Patents and Implications for Infusion Therapy Safety and Efficiency
Authors: Sousa, Liliana B.
Santos-Costa, Paulo
Marques, Inês A. 
Cruz, Arménio 
Salgueiro-Oliveira, Anabela
Parreira, Pedro 
Keywords: double-chamber syringes; flushing; patent review; vascular access devices
Issue Date: 6-Nov-2020
Publisher: MDPI
Project: RESEARCH & TECHNOLOGICAL DEVELOPMENT INCENTIVE SYSTEM (SI I&DT Co-Promotion); grant number POCI-01-0247-FEDER-017604 
SFRH/BD/136487/2018 
SFRH/BD/136973/2018) 
Serial title, monograph or event: International Journal of Environmental Research and Public Health
Volume: 17
Issue: 21
Abstract: This review aimed to map the existing patents of double-chamber syringes that can be used for intravenous drug administration and catheter flush. A search was conducted in the Google patents database for records published prior to 28 October 2020, using several search terms related to double-chamber syringes (DCS). Study eligibility and data extraction were performed by two independent reviewers. Of the initial 26,110 patents found, 24 were included in this review. The 24 DCS that were found display two or more independent chambers that allow for the administration of multiple solutions. While some of the DCS have designated one of the chambers as the flushing chamber, most patents only allow for the sequential use of the flushing chamber after intravenous drug administration. Most DCS were developed for drug reconstitution, usually with a freeze-dried drug in one chamber. Some patents were designed for safety purposes, with a parallel post-injection safety sheath chamber for enclosing a sharpened needle tip. None of the DCS found allow for a pre- and post-intravenous drug administration flush. Given the current standards of care in infusion therapy, future devices must allow for the sequential use of the flushing chamber to promote a pre-administration patency assessment and a post-administration device flush.
URI: https://hdl.handle.net/10316/106187
ISSN: 1660-4601
DOI: 10.3390/ijerph17218209
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBIT - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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