Please use this identifier to cite or link to this item:
Title: Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort
Authors: Gerardo, Bianca 
Pinto, Marina Cabral 
Nogueira, Joana 
Pinto, Paula 
Almeida, Agostinho 
Pinto, Edgar
Marinho-Reis, Paula
Diniz, Luísa
Moreira, Paula I. 
Simões, Mário 
Freitas, Sandra 
Keywords: cognitive decline; human tissues; industrial area; longitudinal study; mining area; nickel; risk for dementia; selenium; trace elements
Issue Date: 20-Aug-2020
Publisher: MDPI
Project: Portuguese Foundation for Science and Technology (Fundação para a Ciência e a Tecnologia (FCT))—grants SFRH/BPD/71030/2010, IF/01325/2015, SFRH/BD/146680/2019, and UIDB/04035/2020. 
Labex DRIIHM, French programme “Investissements d’Avenir” (ANR-11-LABX-0010), which is managed by the ANR 
Serial title, monograph or event: International Journal of Environmental Research and Public Health
Volume: 17
Issue: 17
Abstract: Trace elements (TE) homeostasis is crucial in normal brain functioning. Although imbalances have the potential to exacerbate events leading neurodegenerative diseases, few studies have directly addressed the eventual relationships between TE levels in the human body and future cognitive status. The present study aimed to assess how different TE body-levels relate to cognitive decline. This exploratory research included a study-group (RES) of 20 elderly individuals living in two Portuguese geographical areas of interest (Estarreja; Mértola), as well as a 20 subjects neuropsychological control-group (CTR). Participants were neuropsychologically assessed through the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) and the RES group was biomonitored for TE through fingernail analysis. After 5 years, the cognitive assessments were repeated. Analyses of the RES neuropsychological data showed an average decrease of 6.5 and 5.27 points in MMSE and MoCA, respectively, but TE contents in fingernails were generally within the referenced values for non-exposed individuals. Higher levels of Nickel and Selenium significantly predicted lesser cognitive decline within 5 years. Such preliminary results evidence an association between higher contents of these TE and higher cognitive scores at follow-up, suggesting their contribution to the maintenance of cognitive abilities. Future expansion of the present study is needed in order to comprehensively assess the potential benefits of these TE.
ISSN: 1660-4601
DOI: 10.3390/ijerph17176051
Rights: openAccess
Appears in Collections:I&D CINEICC - Artigos em Revistas Internacionais
FPCEUC - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

Show full item record


checked on Sep 1, 2023


checked on Sep 2, 2023

Page view(s)

checked on Sep 18, 2023


checked on Sep 18, 2023

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons