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Title: Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment
Authors: Rodriguez-Mozaz, Sara
Vaz-Moreira, Ivone
Varela Della Giustina, Saulo
Llorca, Marta
Barceló, Damia 
Schubert, Sara
Berendonk, Thomas U.
Michael-Kordatou, Irene
Fatta-Kassinos, Despo
Martinez, Jose Luis
Elpers, Christian
Henriques, Isabel 
Jaeger, Thomas
Schwartz, Thomas
Paulshus, Erik
O'Sullivan, Kristin
Pärnänen, Katariina M. M.
Virta, Marko
Do, Thi Thuy
Walsh, Fiona
Manaia, Célia M. 
Issue Date: Jul-2020
Publisher: Elsevier
Project: Water JPI through the national funding agencies supporting the consortium WaterJPI/0001/2013 STARE—“Stopping Antibiotic Resistance Evolution” (Cyprus, RPF; Germany, BMBF; Spain, MINECO; Finland, AKA; Ireland, EPA; Norway, RCN; Portugal, FCT) 
Economy and Knowledge Department of the Catalan Government through Consolidated Research Group (ICRA-ENV 2017 SGR 1124 and 2017-SGR-1404-Water and Soil Quality Unit). 
Ramon y Cajal program (RYC-2014-16707) 
FCT grant SFRH/BPD/87360/2012 
Serial title, monograph or event: Environment International
Volume: 140
Abstract: A comprehensive monitoring of a broad set of antibiotics in the final effluent of wastewater treatment plants (WWTPs) of 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out in two consecutive years (2015 and 2016). This is the first study of this kind performed at an international level. Within the 53 antibiotics monitored 17 were detected at least once in the final effluent of the WWTPs, i.e.: ciprofloxacin, ofloxacin, enrofloxacin, orbifloxacin, azithromycin, clarithromycin, sulfapyridine, sulfamethoxazole, trimethoprim, nalidixic acid, pipemidic acid, oxolinic acid, cefalexin, clindamycin, metronidazole, ampicillin, and tetracycline. The countries exhibiting the highest effluent average concentrations of antibiotics were Ireland and the southern countries Portugal and Spain, whereas the northern countries (Norway, Finland and Germany) and Cyprus exhibited lower total concentration. The antibiotic occurrence data in the final effluents were used for the assessment of their impact on the aquatic environment. Both, environmental predicted no effect concentration (PNEC-ENVs) and the PNECs based on minimal inhibitory concentrations (PNEC-MICs) were considered for the evaluation of the impact on microbial communities in aquatic systems and on the evolution of antibiotic resistance, respectively. Based on this analysis, three compounds, ciprofloxacin, azithromycin and cefalexin are proposed as markers of antibiotic pollution, as they could occasionally pose a risk to the environment. Integrated studies like this are crucial to map the impact of antibiotic pollution and to provide the basis for designing water quality and environmental risk in regular water monitoring programs.
ISSN: 01604120
DOI: 10.1016/j.envint.2020.105733
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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