Please use this identifier to cite or link to this item:
Title: Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review
Authors: Campos, Diana
Teixeira, Rogério 
Saleiro, Carolina
Botelho, Ana
Gonçalves, Lino 
Keywords: aortic regurgitation; global longitudinal strain; outcomes; aortic valve replacement
Issue Date: Sep-2020
Publisher: Springer Nature
Serial title, monograph or event: Echo Research and Practice
Volume: 7
Issue: 3
Abstract: Chronic aortic regurgitation (AR) patients typically remain asymptomatic for a long time. Left ventricular mechanics, namely global longitudinal strain (GLS), has been associated with outcomes in AR patients. The authors conducted a systematic review to summarize and appraise GLS impact on mortality, the need for aortic valve replacement (AVR) and disease progression in AR patients. A literature search was performed using these key terms 'aortic regurgitation' and 'longitudinal strain' looking at all randomized and nonrandomized studies conducted on chronic aortic regurgitation. The search yielded six observational studies published from 2011 and 2018 with a total of 1571 patients with moderate to severe chronic AR. Only two studies included all-cause mortality as their endpoint. The other studies looked at the association between GLS with AVR and disease progression. The mean follow-up period was 4.2 years. We noted a great variability of clinical, methodological and/or statistical origin. Thus, meta-analytic portion of our study was limited. Despite a relevant heterogeneity, an impaired GLS was associated with adverse cardiac outcomes. Left ventricular GLS may offer incremental value in risk stratification and decision-making.
ISSN: 2055-0464
DOI: 10.1530/ERP-20-0024
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Show full item record


checked on Sep 1, 2023

Page view(s)

checked on Sep 18, 2023


checked on Sep 18, 2023

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons