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Title: Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review
Authors: Batista, Rui 
Vinagre, Nuno
Meireles, Sara 
Vinagre, João
Prazeres, Hugo 
Leão, Ricardo 
Máximo, Valdemar 
Soares, Paula 
Keywords: bladder cancer; biomarker; TERT promoter mutation; urinary test; blood test; non-invasive test
Issue Date: 13-Jan-2020
Publisher: MDPI
Project: SFRH/BD/111321/2015 
project “Advancing cancer research: from basic knowledge to application” NORTE-01-0145-FEDER-000029: “Projetos Estruturados de I & D & I,” funded by Norte 2020—Programa Operacional Regional do Norte 
PTDC/MED-ONC/31438/2017 (The Other Faces of Telomerase: Looking beyond Tumor Immortalization) 
POCI-01-0145-FEDER-016390: CANCEL STEM 
Serial title, monograph or event: Diagnostics
Volume: 10
Issue: 1
Abstract: Bladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is a complex disease with several molecular and pathological pathways, thus reflecting different behaviors depending on the clinical staging of the tumor and molecular type. Diagnosis and monitoring of BC is mainly performed by invasive tests, namely periodic cystoscopies; this procedure, although a reliable method, is highly uncomfortable for the patient and it is not exempt of comorbidities. Currently, there is no formal indication for the use of molecular biomarkers in clinical practice, even though there are several tests available. There is an imperative need for a clinical non-invasive testing for early detection, disease monitoring, and treatment response in BC. In this review, we aim to assess and compare different tests based on molecular biomarkers and evaluate their potential role as new molecules for bladder cancer diagnosis, follow-up, and treatment response monitoring.
ISSN: 2075-4418
DOI: 10.3390/diagnostics10010039
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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