Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105887
DC Field | Value | Language |
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dc.contributor.author | Fadiga, Lúcia | - |
dc.contributor.author | Saraiva, Joana | - |
dc.contributor.author | Catarino, Diana | - |
dc.contributor.author | Frade, João | - |
dc.contributor.author | Melo, Miguel | - |
dc.contributor.author | Paiva, Isabel | - |
dc.date.accessioned | 2023-03-14T10:45:20Z | - |
dc.date.available | 2023-03-14T10:45:20Z | - |
dc.date.issued | 2020-12-03 | - |
dc.identifier.issn | 1758-5996 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105887 | - |
dc.description.abstract | Introduction: Adult-onset autoimmune diabetes (AID) has two different phenotypes: classic type 1 diabetes mellitus (T1DM), with insulin requirement just after diagnosis, and latent autoimmune diabetes in adults (LADA). The purpose of this study is to characterize patients with AID followed on a tertiary centre, comparing classic T1DM and LADA. Methods: We collected data from patients with diabetes and positive islet autoantibodies, aged 30 years old and over at diagnosis. Patients who started insulin in the first 6 months were classified as T1DM and patients with no insulin requirements in the first 6 months were classified as LADA. Data regarding clinical presentation, autoantibodies, A1C and C-peptide at diagnosis, pharmacologic treatment and complications were analysed. Results: We included 92 patients, 46 with classic T1DM and 46 with LADA. The percentage of females was 50% in T1DM group and 52.1% in LADA group. The median age at diagnosis was 38 years (IQR–15) for T1DM and 42 years (IQR–15) for LADA (p = 0.057). The median time between diagnosis of diabetes and diagnosis of autoimmune aetiology was 0 months in T1DM group and 60 months in LADA group (p < 0.001). The mean BMI at diagnosis was 24.1 kg/ m2 in T1DM group and 26.1 kg/m2 in LADA group (p = 0.042). In T1DM group, 67.4% of the patients had more than one positive autoantibody, comparing to 41.3% of LADA patients (p = 0.012). There was no statistical difference in what concerns to title of GAD autoantibodies, A1C and C-peptide at diagnosis of autoimmune aetiology. The presence of symptoms at diagnosis was associated with T1DM group (p < 0.001). The median daily insulin dose was 40 IU for T1DM (0.58 IU/kg) and 33.5 IU for LADA (0.57 IU/kg), with no statistical difference. LADA patients were more often under non-insulin antidiabetic drugs (p = 0.001). At 10 years follow up, 21.1% of T1DM patients and 63.3% of LADA patients had microvascular complications (p = 0.004). Diabetic nephropathy was present in 23.5% of T1DM patients and 53.3% of LADA patients (p = 0.047). At the last evaluation, 55.6% of T1DM and 82.6% of LADA patients had metabolic syndrome and this difference was independent of diabetes duration. Conclusion: Patients with classic T1DM presented more often with symptoms, lower BMI and higher number of autoantibodies, which may be related to a more aggressive autoimmune process. Patients with LADA developed more frequently microvascular complications for the same disease duration, namely diabetic nephropathy, and had more often metabolic syndrome. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Autoimmune disease | pt |
dc.subject | Diabetes complications | pt |
dc.subject | Diabetes mellitus | pt |
dc.subject | type 1 | pt |
dc.subject | Latent autoimmune diabetes in adults | pt |
dc.subject | Insulin resistance | pt |
dc.title | Adult-onset autoimmune diabetes: comparative analysis of classical and latent presentation | pt |
dc.type | article | - |
degois.publication.firstPage | 107 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Diabetology and Metabolic Syndrome | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/s13098-020-00616-1 | pt |
degois.publication.volume | 12 | pt |
dc.date.embargo | 2020-12-03 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Adultonset-autoimmune-diabetes-comparative-analysis-of-classical-and-latent-presentationDiabetology-and-Metabolic-Syndrome.pdf | 921.93 kB | Adobe PDF | View/Open |
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