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Title: Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats
Authors: Maia, Cristiane
Pinheiro, Bruno Gonçalves
Soares da Silva, Carla Cristiane
Cunha, Rodrigo A. 
Souza-Monteiro, Deiweson
Martins Ferreira, Maria Karolina
Schmidt, Tuany Rafaeli
de Souza Balbinot, Gabriela
Collares, Fabrício Mezzomo
Martins, Manoela Domingues
Lima, Rafael Rodrigues
Keywords: Binge drinking; Caffeine; Adenosine A2A receptor; Adolescence; Alveolar bone loss; Periodontitis
Issue Date: Oct-2020
Publisher: Elsevier
Project: Programa Nacional de Cooperação Acadêmica na Amazônia – PROCAD/Amazônia da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior –CAPES/Brasil and by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) Finance Cod 001 
Research Pro-Rectory of the Federal University of Pará (PROPESP, UFPA, Brazil) 
La Caixa Foundation (LCF/PR/HP17/52190001) 
CENTRO-01-0145-FEDER- 000008:BrainHealth 2020 
research fellowship from CNPq 
Serial title, monograph or event: Biomedicine and Pharmacotherapy
Volume: 130
Abstract: Ethanol consumption has been reported to negatively impact on periodontal disease. In particular, oral cavity disorders occur upon ethanol exposure during adolescence, a life period associated with particular patterns of short and intense ('binge-like') ethanol consumption that is most deleterious to oral health. The hazardous central effects of ethanol have been linked to the overfunction of adenosine receptors, which are antagonized by caffeine, a bioactive substance present in numerous natural nutrients, which can also modify bone metabolism. The aim of this study was to investigate the effects of caffeine on alveolar bone damage induced by an ethanol binge drinking paradigm during adolescence. Female Wistar rats (35 days old; n = 30) were allocated to six groups: control (vehicle), ethanol (3 g/kg/day; 3 days On-4 days Off challenge), caffeine (10 mg/kg/day), caffeine plus ethanol, SCH58261 (0.1 mg/kg/day, an antagonist of A2A receptors), and SCH58261 plus ethanol. Bone micromorphology and vertical bone loss were analyzed by computed microtomography. Our data showed that ethanol binge drinking reduced alveolar bone quality, with repercussion on alveolar bone size. This ethanol-induced alveolar bone deterioration was abrogated upon treatment with caffeine, but not with SCH58261. This shows that caffeine prevented the periodontal disorder caused by ethanol binge drinking during adolescence, an effect that was not mediated by adenosine A2A receptor blockade.
ISSN: 07533322
DOI: 10.1016/j.biopha.2020.110608
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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