Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105341
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Torrado-Salmerón, Carlos | - |
dc.contributor.author | Guarnizo-Herrero, Víctor | - |
dc.contributor.author | Henriques, Joana | - |
dc.contributor.author | Seiça, Raquel | - |
dc.contributor.author | Sena, Cristina M. | - |
dc.contributor.author | Torrado-Santiago, Santiago | - |
dc.date.accessioned | 2023-02-17T12:07:49Z | - |
dc.date.available | 2023-02-17T12:07:49Z | - |
dc.date.issued | 2021-03-20 | - |
dc.identifier.issn | 1999-4923 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105341 | - |
dc.description.abstract | The aim of this study was to develop multiparticulate systems with a combination of ezetimibe micellar systems and atorvastatin solid dispersions using croscarmellose as a hydrophilic vehicle and Kolliphor RH40 as a surfactant. The presence of a surfactant with low hydrophilic polymer ratios produces the rapid dissolution of ezetimibe through a drug-polymer interaction that reduces its crystallinity. The solid dispersion of atorvastatin with low proportions of croscarmellose showed drug-polymer interactions sufficient to produce the fast dissolution of atorvastatin. Efficacy studies were performed in diabetic Goto-Kakizaki rats with induced hyperlipidemia. The administration of multiparticulate systems of ezetimibe and atorvastatin at low (2 and 6.7 mg/kg) and high (3 and 10 mg/kg) doses showed similar improvements in levels of cholesterol, triglycerides, lipoproteins, alanine transaminase, and aspartate transaminase compared to the high-fat diet group. Multiparticulate systems at low doses (2 and 6.7 mg/kg of ezetimibe and atorvastatin) had a similar improvement in hepatic steatosis compared to the administration of ezetimibe and atorvastatin raw materials at high doses (3 and 10 mg/kg). These results confirm the effectiveness of solid dispersions with low doses of ezetimibe and atorvastatin to reduce high lipid levels and hepatic steatosis in diabetic rats fed a high-fat diet. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | PTDC/BIM-MET/4447/2014 | pt |
dc.relation | POCI-01-0145-FEDER-016784 | pt |
dc.relation | Ministerio de Ciencia e Innovación [MICINU, ref. RTI2018-093940-B-100] | pt |
dc.relation | UCM [Research Group 910939] | pt |
dc.relation | Rafael Folch Foundation | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | ezetimibe | pt |
dc.subject | atorvastatin | pt |
dc.subject | solid dispersion | pt |
dc.subject | micellar system | pt |
dc.subject | hyperlipidemia | pt |
dc.subject | liver steatosis | pt |
dc.title | Multiparticulate Systems of Ezetimibe Micellar System and Atorvastatin Solid Dispersion Efficacy of Low-Dose Ezetimibe/Atorvastatin on High-Fat Diet-Induced Hyperlipidemia and Hepatic Steatosis in Diabetic Rats | pt |
dc.type | article | - |
degois.publication.firstPage | 421 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | Pharmaceutics | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/pharmaceutics13030421 | pt |
degois.publication.volume | 13 | pt |
dc.date.embargo | 2021-03-20 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CMTS2015_2020 .: Crosstalk entre o tecido adiposo perivascular e os vasos sanguíneos na obesidade e diabetes tipo 2 | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-0102-7988 | - |
crisitem.author.orcid | 0000-0002-8378-0895 | - |
crisitem.author.orcid | 0000-0002-0889-2977 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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