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Title: Naringenin Nano-Delivery Systems and Their Therapeutic Applications
Authors: Bhia, Mohammed
Motallebi, Mahzad
Abadi, Banafshe
Zarepour, Atefeh
Silva, Miguel Pereira da 
Saremnejad, Farinaz
Santos, Ana Cláudia 
Zarrabi, Ali
Melero, Ana
Jafari, Seid Mahdi
Shakibaei, Mehdi
Keywords: naringenin; nutraceuticals; antioxidants; natural products; nanoparticles; drug delivery; nanomedicine; bioavailability; flavonoid
Issue Date: 23-Feb-2021
Publisher: MDPI
Project: University of Valencia and the Valencian Government (grant numbers UV-19-INV_AE19 and GV2015-054) 
Serial title, monograph or event: Pharmaceutics
Volume: 13
Issue: 2
Abstract: Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nanoemulsions. These nanomedicine formulations of NRG have been applied as a potential treatment for several diseases, using a wide range of in vitro, ex vivo, and in vivo models and different routes of administration. From this review, it can be concluded that NRG is a potential therapeutic option for the treatment of various diseases such as cancer, neurological disorders, liver diseases, ocular disorders, inflammatory diseases, skin diseases, and diabetes when formulated in the appropriate nanocarriers.
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics13020291
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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