Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/105284
Title: Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
Authors: Gonçalves, Joana
Nunes, Cláudia
Ferreira, Liliana 
Cruz, Maria Margarida
Oliveira, Helena
Bastos, Verónica
Mayoral, Álvaro
Zhang, Qing
Ferreira, Paula
Keywords: magnetic nanoparticles; magnetite; fucoidan; magnetic hyperthermia therapy; biocompatibility
Issue Date: 2-Nov-2021
Publisher: MDPI
Project: UIDB/50011/2020 
UIDP/50011/2020 
PTDC/NAN-MAT/28785/2017 
UID/MULTI/04046/2019 
POCI-01-0145-FEDER-031794 
UIDB/50017/2020 
SFRH/BPD/100627/2014 
UIDP/50017/2020 
Serial title, monograph or event: Nanomaterials
Volume: 11
Issue: 11
Abstract: Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m-1 and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm2kg-1, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.
URI: https://hdl.handle.net/10316/105284
ISSN: 2079-4991
DOI: 10.3390/nano11112939
Rights: openAccess
Appears in Collections:FCTUC Física - Artigos em Revistas Internacionais

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