Please use this identifier to cite or link to this item:
Title: Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
Authors: Gonçalves, Joana
Nunes, Cláudia
Ferreira, Liliana 
Cruz, Maria Margarida
Oliveira, Helena
Bastos, Verónica
Mayoral, Álvaro
Zhang, Qing
Ferreira, Paula
Keywords: magnetic nanoparticles; magnetite; fucoidan; magnetic hyperthermia therapy; biocompatibility
Issue Date: 2-Nov-2021
Publisher: MDPI
Project: UIDB/50011/2020 
UIDP/50017/2020 & UIDB/50017/2020 
FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. 
FCT - IF/00300/2015 
FCT - CEECIND/04050/2017 
FCT - Post-Doctoral grant SFRH/BPD/100627/2014 
Spanish Ministry of Science (RYC2018-024561-I) 
Natural National Science Foundation of China through the grants NSFC- 21850410448 & NSFC- 21835002 
The Centre for High-resolution Electron Microscopy (C¯hEM), supported by SPST of ShanghaiTech University under contract No. EM02161943 
European Union’s Horizon 2020 research and innovation programme under grant agreement No 823717—ESTEEM3 
Serial title, monograph or event: Nanomaterials
Volume: 11
Issue: 11
Abstract: Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m-1 and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm2kg-1, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.
ISSN: 2079-4991
DOI: 10.3390/nano11112939
Rights: openAccess
Appears in Collections:FCTUC Física - Artigos em Revistas Internacionais

Show full item record


checked on Nov 27, 2023


checked on Nov 2, 2023

Page view(s)

checked on Nov 28, 2023


checked on Nov 28, 2023

Google ScholarTM




This item is licensed under a Creative Commons License Creative Commons