Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105259
DC Field | Value | Language |
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dc.contributor.author | Silva, Inês M. V. | - |
dc.contributor.author | Machado, Fernanda | - |
dc.contributor.author | Moreno, Maria João | - |
dc.contributor.author | Nunes, Cláudia | - |
dc.contributor.author | Coimbra, Manuel A. | - |
dc.contributor.author | Coreta-Gomes, Filipe | - |
dc.date.accessioned | 2023-02-13T10:43:56Z | - |
dc.date.available | 2023-02-13T10:43:56Z | - |
dc.date.issued | 2021-07-28 | - |
dc.identifier.issn | 1420-3049 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105259 | - |
dc.description.abstract | Several classes of polysaccharides have been described to have hypocholesterolemic potential, namely cholesterol bioaccessibility and bioavailability. This review will highlight the main mechanisms by which polysaccharides are known to affect cholesterol homeostasis at the intestine, namely the effect (i) of polysaccharide viscosity and its influence on cholesterol bioaccessibility; (ii) on bile salt sequestration and its dependence on the structural diversity of polysaccharides; (iii) of bio-transformations of polysaccharides and bile salts by the gut microbiota. Different quantitative structure-hypocholesterolemic activity relationships have been explored depending on the mechanism involved, and these were based on polysaccharide physicochemical properties, such as sugar composition and ramification degree, linkage type, size/molecular weight, and charge. The information gathered will support the rationalization of polysaccharides' effect on cholesterol homeostasis and highlight predictive rules towards the development of customized hypocholesterolemic functional food. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UID/QUI/00062/2019 | pt |
dc.relation | UIDB/50006/2020 | pt |
dc.relation | UIDB/50011/2020 | pt |
dc.relation | UIDP/50011/2020 | pt |
dc.relation | UIDB/00313/2020 | pt |
dc.relation | UIDP/00313/2020 | pt |
dc.relation | PTDC/QUI-OUT/29373/2017 | pt |
dc.relation | POCI- 01-0145-FEDER-031032 | pt |
dc.relation | FCT - PhD fellowship with the reference 2020.06768.BD | pt |
dc.relation | national funds (OE), through FCT, I.P., within the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | polysaccharides | pt |
dc.subject | chitosan | pt |
dc.subject | β-glucans | pt |
dc.subject | cholesterol homeostasis | pt |
dc.subject | viscosity | pt |
dc.subject | bile salt sequestration | pt |
dc.subject | microbiota | pt |
dc.subject | hypocholesterolemic ingredients; | pt |
dc.subject | fiber | pt |
dc.subject.mesh | Anticholesteremic Agents | pt |
dc.subject.mesh | Bile Acids and Salts | pt |
dc.subject.mesh | Biological Availability | pt |
dc.subject.mesh | Biotransformation | pt |
dc.subject.mesh | Cholesterol | pt |
dc.subject.mesh | Functional Food | pt |
dc.subject.mesh | Gastrointestinal Microbiome | pt |
dc.subject.mesh | Homeostasis | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Intestinal Mucosa | pt |
dc.subject.mesh | Liver | pt |
dc.subject.mesh | Molecular Structure | pt |
dc.subject.mesh | Molecular Weight | pt |
dc.subject.mesh | Polysaccharides | pt |
dc.subject.mesh | Static Electricity | pt |
dc.title | Polysaccharide Structures and Their Hypocholesterolemic Potential | pt |
dc.type | article | - |
degois.publication.firstPage | 4559 | pt |
degois.publication.issue | 15 | pt |
degois.publication.title | Molecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/molecules26154559 | pt |
degois.publication.volume | 26 | pt |
dc.date.embargo | 2021-07-28 | * |
uc.date.periodoEmbargo | 0 | pt |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
crisitem.project.grantno | Associated Laboratory for Green Chemistry - Clean Technologies and Processes- REQUIMTE | - |
crisitem.project.grantno | CICECO-Aveiro Institute of Materials | - |
crisitem.project.grantno | CICECO-Aveiro Institute of Materials | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.author.orcid | 0000-0003-2456-4508 | - |
crisitem.author.orcid | 0000-0001-9498-2460 | - |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Polysaccharide-structures-and-their-hypocholesterolemic-potentialMolecules.pdf | 1.01 MB | Adobe PDF | View/Open |
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