Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/104755
Title: Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-of-the-Art and Future Directions
Authors: Lobo, João 
Leão, Ricardo 
Jerónimo, Carmen 
Henriques, Rui T. 
Keywords: germ cell tumors; liquid biopsies; microRNAs; DNA methylation; circulating tumor cells; biomarkers; diagnosis; follow-up; serum tumor markers
Issue Date: 6-Mar-2021
Publisher: MDPI AG
Project: project EpiMarkGermCell (PTDC/MEC-URO/29043/2017 
FCT - SFRH/BD/132751/2017 
MSD (“Prémio de Investigação em Saúde”), Banco Carregosa/ Secção Regional do Norte da Ordem dos Médicos (SRNOM) and Fundação Rui Osório de Castro/Millennium bcp. 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 22
Issue: 5
Abstract: Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we provide an overall review of the current liquid biopsy-based biomarkers of this disease, including the classical, routinely used serum tumor markers-the promising microRNAs rapidly approaching the introduction into clinical practice-but also cell-free DNA markers (including DNA methylation) and circulating tumor cells. Finally, and importantly, we also explore novel strategies and challenges for liquid biopsy markers and methodologies, providing a critical view of the future directions for liquid biopsy tests in this field, highlighting gaps and unanswered questions.
URI: https://hdl.handle.net/10316/104755
ISSN: 1422-0067
DOI: 10.3390/ijms22052654
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Show full item record

SCOPUSTM   
Citations

16
checked on Sep 30, 2024

WEB OF SCIENCETM
Citations

15
checked on Oct 2, 2024

Page view(s)

75
checked on Oct 8, 2024

Download(s)

63
checked on Oct 8, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons