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Title: Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies
Authors: Serrenho, Inês 
Rosado, Miguel 
Dinis, Alexandra
M Cardoso, Carla
Grãos, Mário 
Manadas, Bruno 
Baltazar, Graça Maria Fernandes 
Keywords: hypoxic-ischemic encephalopathy; stem cell therapy; umbilical cord blood cells; umbilical cord tissue; mesenchymal stem/stromal cells; therapeutic hypothermia
Issue Date: 19-Mar-2021
Publisher: MDPI AG
Project: POCI-01–0145-FEDER-029311 (ref.: PTDC/BTM-TEC/29311/2017) 
POCI-01– 0145-FEDER-016428 (ref.: SAICTPAC/0010/2015) 
POCI-01–0145-FEDER-016795 (ref.: PTDC/NEUSCC/ 7051/2014) 
POCI-01–0145-FEDER-029516 (PTDC/MED-NEU/29516/2017) 
RescueCord POCI- 01–0247-FEDER-045311 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 22
Issue: 6
Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in the perinatal period. This condition results from a period of ischemia and hypoxia to the brain of neonates, leading to several disorders that profoundly affect the daily life of patients and their families. Currently, therapeutic hypothermia (TH) is the standard of care in developing countries; however, TH is not always effective, especially in severe cases of HIE. Addressing this concern, several preclinical studies assessed the potential of stem cell therapy (SCT) for HIE. With this systematic review, we gathered information included in 58 preclinical studies from the last decade, focusing on the ones using stem cells isolated from the umbilical cord blood, umbilical cord tissue, placenta, and bone marrow. Outstandingly, about 80% of these studies reported a significant improvement of cognitive and/or sensorimotor function, as well as decreased brain damage. These results show the potential of SCT for HIE and the possibility of this therapy, in combination with TH, becoming the next therapeutic approach for HIE. Nonetheless, few preclinical studies assessed the combination of TH and SCT for HIE, and the existent studies show some contradictory results, revealing the need to further explore this line of research.
ISSN: 1422-0067
DOI: 10.3390/ijms22063142
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais

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