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https://hdl.handle.net/10316/104651
Title: | Study Protocol of a Multicenter Randomized Controlled Trial to Tackle Obesity through a Mediterranean Diet vs. a Traditional Low-Fat Diet in Adolescents: The MED4Youth Study | Authors: | Boqué, Noemi Tarro, Lucía Rosi, Alice Torrell, Helena Saldaña, Guillermo Luengo, Elisa Rachman, Zeev Pires, António Tavares, Nuno Tiago Pires, Ana Salomé Botelho, Maria Filomena Mena, Pedro Scazzina, Francesca Del Rio, Daniele Caimari, Antoni |
Keywords: | adolescents; youth obesity; Mediterranean diet; cardiovascular risk factors; educational approach; healthy food products; omics; gut microbiota | Issue Date: | 1-May-2021 | Publisher: | MDPI AG | Project: | PRIMA programme supported by the European Union. It is financially supported by the Agency for Business Competitiveness of the Government of Catalonia (ACCIÓ) [TECCT11-1-0012], the Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation, the Israel Innovation Agency, the Ministerio dell’istruzione, dell’università e della ricerca MIUR, the Scientific Research Support Fund, the Foundation for Science and Technology (FCT) CDTI under grant agreement: TECNOMIFOOD project. CER-20191010 |
Serial title, monograph or event: | International Journal of Environmental Research and Public Health | Volume: | 18 | Issue: | 9 | Abstract: | Youth obesity is a strong predictor of adult obesity, which has well-known negative health consequences. Thus, addressing adult obesity requires tackling youth obesity. MED4Youth's main objective is to strengthen the link between the Mediterranean Diet (MD) and the health benefits against youth obesity and associated cardiovascular disease (CVD) risk factors, identifying positive effects exerted by an MD including sourdough bread and healthy products from the Mediterranean basis (chickpeas/hummus, nuts, and pomegranate juice). For this purpose, a multicenter randomized controlled trial in which an MD-based intervention will be compared to a traditional low-fat diet intervention will be carried out with 240 overweight and obese adolescents (13-17 years) from Spain, Portugal, and Italy. Both interventions will be combined with an educational web-application addressed to engage the adolescents through a learning-through-playing approach, using both educational materials and games. To assess the interventions, adherence to the MD, dietary records, physical activity, food frequency, sociodemographic, and quality of life questionnaires as well as classical anthropometric and biochemical parameters will be evaluated. Furthermore, an omics approach will be performed to elucidate whether the interventions can shape the gut microbiota and gut-derived metabolites to gain knowledge on the mechanisms through which the MD can exert its beneficial effects. | URI: | https://hdl.handle.net/10316/104651 | ISSN: | 1660-4601 | DOI: | 10.3390/ijerph18094841 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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